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晩期障害マウスモデルを用いた重粒子線治療有害事象の検討
https://repo.qst.go.jp/records/55619
https://repo.qst.go.jp/records/55619c9d7b078-4b53-4d3f-8a37-0cc07cff732e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-03 | |||||
| タイトル | ||||||
| タイトル | 晩期障害マウスモデルを用いた重粒子線治療有害事象の検討 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柳澤, 充
× 柳澤, 充× 盛武, 敬× 中渡, 美也子× 今留, 香織× 酒井, 美奈子× 中村, 悦子× 岩川, 眞由美× 今井, 高志× 柳澤 充× 盛武 敬× 中渡 美也子× 今留 香織× 酒井 美奈子× 中村 悦子× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose---To clarify the molecular mechanism of radiation induced late injury in normal tissue, using murine model. In the first year of this study, aiming to irradiate the lung or the urinary bladder of mice with carbon-ion, new type of collimators was constructed. Materials and methods --- C3H/HeNrs and C57BL/6J, 8-week-old female mice were used through experiments. The position of the target, either lung or bladder, was confirmed by x-ray photographs. Also, the absorbed dose at the target was confirmed using photoluminescence dosimeter (PLD) and ionization chamber. Exposures were conducted using horizontal carbon-12 beams with 290 MeV/u at a dose rate of approximately 3 Gy/min within the 6-cm spread-out bragg peak (SOBP). Gamma-rays were used as reference beam with new collimators. To evaluate the effects of C-ion irradiation on lungs, pathological changes and immunohistochemical stainings for CD44 and Bak at 6 hr, day16, 28 and 56 after thoracic irradiation were analyzed. To evaluate the adverse effects on the bladder,cystometry and pathological evaluation were performed.The total RNA was extracted from irradiated tissues, which were removed on day1,4,8,15,29,60,90,150,240 and 360 after irradiation for microarray analysis to elucidate the molecular response to irradiation. Results --- The number of CD44 and Bak positive cells in the irradiated lungs were changed after irradiation. The capacity of the urinary bladder and the compliance were decreased significantly at day1,4,8 and 29 after irradiation. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-214, 号 HAIMAC-129, p. 51-52, 発行日 2008-06 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
