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Age dependence of heavy-ion mammary carcinogenesis
https://repo.qst.go.jp/records/55579
https://repo.qst.go.jp/records/555791f7ab4a4-310c-4386-b7d8-9427c3e6f5b4
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-07 | |||||
| タイトル | ||||||
| タイトル | Age dependence of heavy-ion mammary carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Ohmachi, Yasushi× Kakinuma, Shizuko× Yamauchi, Kazumi× Nakata, Akifumi× Shang, Yi× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 大町 康× 柿沼 志津子× 山内 一己× 中田 章史× 尚 奕× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Risk of secondary cancers from heavy ion therapy is not well understood. We previously demonstrated that carbon ion irradiation potently induced rat mammary tumors effectively. Because juvenile exposure to ionizing radiation is known to cause high risk of breast cancer, application of heavy ion therapy to childhood cancers should be based on the information on age de¬pen¬dence of secondary cancer induction. In the present study, we irradiated female Spra¬gue-Dawley rats with 290 MeV/u car¬bon ions at 3, 13 and 17 days postcoitum and at 1, 3, 7 and 15 weeks postnatal. Of a total of 893 rats, observation was finished for 492 rats and macroscopic mammary tumors were counted. The preliminary result shows that adulthood (7 and 15 weeks of age) is a more susceptible period than fetal and juvenile periods. Path¬o¬log¬i¬cal analysis is currently in progress. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC p. 48-50, 発行日 2007-06 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
