{"_buckets": {"deposit": "ca02ab2e-db17-4546-9309-f21a8c704d3f"}, "_deposit": {"created_by": 1, "id": "55495", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "55495"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00055495", "sets": ["7"]}, "author_link": ["567505", "567508", "567506", "567501", "567511", "567507", "567498", "567512", "567503", "567499", "567500", "567509", "567510", "567502", "567504"], "item_10004_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-04", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "50", "bibliographicPageStart": "49", "bibliographicVolumeNumber": "2001", "bibliographic_titles": [{"bibliographic_title": "放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書"}]}]}, "item_10004_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Tenascin-C is an extracellular matrix glycoprotein upregulated in various pathological processes such as wound healing,, cancer invasion or inflammation. In this study, we examined the possibility of radioiodinated anti Tenascin-C antibody Fab\u0027 fragment (125I-TN-C) for estimating therapeutic efficacy of carbon ion therapy (270 Mev, 25 Gy) to C-10 glioma xenografts in nude mice. In addition, since radioiodinated 3-[125I]iodo-alpha-methyl-L-tyrosine (125I-IMT) is currently being used as a diagnostic regent of brain tumor, therapeutic effects of ion therapy was also estimated using the radiopharmaceutical. After carbon beam irradiation of left leg of nude mice without tumor, the damage of irradiation site was increased with times. The uptake of 125I-TN-C in irradiation site was also increased (irradiation site-to-non-irradiation site 4.15+/-0.95). At 10 and 20 days post-carbon ion therapy, however, no significant differences were observed between the tumor site and control leg. The radioactivity levels in the tumor were lower than those in the blood. On the other hand, 125I-IMT accumulated in tumor but not in irradiation site. The tumor-to-blood and the irradiation site-to-non-irradiation site ratios of the radioactivity were 5.96+/-1.00 and 1.57+/-0.70, respectively. These results suggested that 125I-TN-C may not be suitable for estimating therapeutic efficacy of carbon ion therapy, whereas 125I-IMT may be a promising regent for estimating therapeutic effects of carbon ion therapy.", "subitem_description_type": "Abstract"}]}, "item_10004_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "放医研"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "荒野, 泰"}], "nameIdentifiers": [{"nameIdentifier": "567498", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "上原, 知也"}], "nameIdentifiers": [{"nameIdentifier": "567499", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "宮本, 重彦"}], "nameIdentifiers": [{"nameIdentifier": "567500", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安藤, 興一"}], "nameIdentifiers": [{"nameIdentifier": "567501", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中田, 英夫"}], "nameIdentifiers": [{"nameIdentifier": "567502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "吉田, 利通"}], "nameIdentifiers": [{"nameIdentifier": "567503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "井上, 修"}], "nameIdentifiers": [{"nameIdentifier": "567504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "入江, 俊章"}], "nameIdentifiers": [{"nameIdentifier": "567505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "荒野 泰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "上原 知也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "宮本 重彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安藤 興一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中田 英夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "井上 修", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "入江 俊章", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "567512", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ラジオアイソトープ標識抗テネイシンC抗体を用いる重粒子線治療の効果判定と適用腫瘍の選定", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ラジオアイソトープ標識抗テネイシンC抗体を用いる重粒子線治療の効果判定と適用腫瘍の選定"}]}, "item_type_id": "10004", "owner": "1", "path": ["7"], "permalink_uri": "https://repo.qst.go.jp/records/55495", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-07-03"}, "publish_date": "2006-07-03", "publish_status": "0", "recid": "55495", "relation": {}, "relation_version_is_last": true, "title": ["ラジオアイソトープ標識抗テネイシンC抗体を用いる重粒子線治療の効果判定と適用腫瘍の選定"], "weko_shared_id": -1}