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重粒子線治療の最適化のための生物学研究-III 腫瘍の感受性とLET
https://repo.qst.go.jp/records/55411
https://repo.qst.go.jp/records/5541119c0a918-190b-41d2-9ffc-c5972aff0c4f
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-11-04 | |||||
| タイトル | ||||||
| タイトル | 重粒子線治療の最適化のための生物学研究-III 腫瘍の感受性とLET | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
安藤, 興一
× 安藤, 興一× 古澤, 佳也× 鵜澤, 玲子× 小池, 幸子× 高井, 伸彦× 青木, 瑞穂× 扶川, 武志× 宮戸, 靖幸× 平山, 亮一× 物部, 真奈美× 安藤 興一× 古澤 佳也× 鵜澤 玲子× 小池 幸子× 高井 伸彦× 青木 瑞穂× 扶川 武志× 宮戸 靖幸× 平山 亮一× 物部 真奈美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Biological effectiveness of high LET particle beams on tumors was investigated to find optimum use of the beams in clinical use. First, we obtained and compared 10 cell lines of malignant melanoma and 11 cell lines of squamous cell carcinoma originated from human patients. Survival parameters were deduced from each cell lines that received a single dose of 50 keV/um carbon ions. When we plot X-ray values and carbon-ion values on X- and y- axis, respectively, alpha/beta ratio was only the parameter that distinguish malignant melanoma from squamous cell carcinoma. We have selected several cell lines to analyze and compare protein expression between the two types of malignancy. Second, DNA synthesis of irradiated tumors were measured by counting radiolabeled thymidine after an IV injection to HSG tumor?bearing nude mice. When tumor blood flows were shut by clamping before irradiation, incorporation thymidine into tumors was lower for the clamped tumors than non-clamped tumors 24 hr but not 12 hr after clamping/irradiation. Third, relation between tumor growth rate and RBE of carbon ions were investigated. Usig 11 tumors transplanted into syngeneic C3H mice, we found RBE of carbon ions (20-74 keV/um) did not depend on tumor growth rate. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2005, p. 43-45, 発行日 2005-05 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
