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炭素線治療の生物学的優位性
https://repo.qst.go.jp/records/55372
https://repo.qst.go.jp/records/5537256e21e28-037c-4acf-9090-93fade043857
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-02-08 | |||||
| タイトル | ||||||
| タイトル | 炭素線治療の生物学的優位性 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
安藤, 興一
× 安藤, 興一× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A question whether high LET radiotherapy be advantageous was answered by in vivo experiments. The biological effectiveness of carbon ions relative to gamma rays (RBE) was compared between the tumor growth delay and an early skin reaction of syngeneic mice. The RBE was larger for a tumor than skin when irradiated with large doses of high-LET (linear energy transfer) carbon ions. The intra-track damage (alpha term of a linear quadratic model) of a tumor and skin equally increased with an increase of the LET, while the inter-track damage (beta term) of skin alone increased with the LET. These data provide evidence that high-LET radiotherapy could achieve therapeutic gain by minimizing the difference in response to fractionated irradiation between the tumor and normal tissue. | |||||
| 書誌情報 |
HIMAC10年の歩み : HIMAC10周年記念研究成果要覧 p. 136-144, 発行日 2004 |
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| 出版者 | ||||||
| 出版者 | 放射線医学総合研究所 | |||||
