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頭頚部領域における炭素イオン線の臨床試験研究成果
https://repo.qst.go.jp/records/55353
https://repo.qst.go.jp/records/55353f641a9b5-4d91-479f-b218-a9d6890de05a
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-01-11 | |||||
| タイトル | ||||||
| タイトル | 頭頚部領域における炭素イオン線の臨床試験研究成果 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
溝江, 純悦
× 溝江, 純悦× 長谷川, 安都佐× 山本, 信治× 辻井, 博彦× 今野, 昭義× 岡本, 美孝× その他× 溝江 純悦× 長谷川 安都佐× 山本 信治× 辻井 博彦× 今野 昭義× 岡本 美孝 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Base on the results of Phase I/II dose escalation studis from June 1994 to February 1997, we have started phase II clinical trials in order to determine the effectiveness of carbon ion radiotherapy for head and neck cancer. Between April 1997 and October 2003, a total of 193 patients were entered into a phase II study of carbon ion radiotherapy. Of then, 173 patients(175 sites) were treated between April 1977 and February 2003 and were candidates for this analysis. A total of 134 cases were irradiated by 57.6 GyE/16 fractions and a total of 20 cases were irradiated by 64.0 GyE/16 fractions. A grade 3 skin rezction was observed in 8.6% and a grade 3 mucosal reaction was obsrved in 12.3%. There was no grade 4 or greater acute reaction. A grade 2 late skin reaction was seen in 5.3% and a grade 2 late mucosal reaction in 3.1%. No grade 3 or greater late reaction was seen before the time of analysis. The local control rate of 57 patients with malignant melanoma was 82%, 36 adenoid cystic carcinoma 57%, 15 adenocarcinoma 92% and 10 squamous cell carcinomas 61% at 5 years. Preliminary results of Phase II clinical trial for head and neck cancer are showing acceptable acute and late morbidity with excellent local control of the tumors. These results observed in carbon ion radiotherapy zppear promising compared with those achieve by low-LET irradiation. |
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| 書誌情報 |
HIMAC10年の歩み : HIMAC10周年記念研究成果要覧 p. 19-25, 発行日 2004-07 |
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| 出版者 | ||||||
| 出版者 | 放射線医学総合研究所 | |||||
