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脳の正常組織と高次脳機能に対する重粒子線の影響解析
https://repo.qst.go.jp/records/55262
https://repo.qst.go.jp/records/55262b656f544-0ac4-487d-8e2d-52edd6b8b9df
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-02-07 | |||||
| タイトル | ||||||
| タイトル | 脳の正常組織と高次脳機能に対する重粒子線の影響解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
野島, 久美恵
× 野島, 久美恵× 劉, 翠華× 長岡, 俊治× 野島 久美恵× 劉 翠華× 長岡 俊治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of low dose heavy particle radiation to central nervous system were studied using mouse neonatal brain cells in culture exposed to heavy ions and X ray at fifth days of the culture. The subsequent biological effects were evaluated by an induction of apoptosis and the survivability of neurons focusing on the dependencies of (1) the animal strains with different genetic types, and (2) LET of the different nucleons. Of the three mouse strains tested, SCID, B6 and C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to both X-ray and carbon ion (290MeV/n) when compared by 10 % apoptotic induction. The LET dependency was compared with using SCID cells exposing to different ions, (X, C, Si, Ar, and Fe). Although no detectable LET dependency was observed at higher dose than 1 Gy, an enhancement was observed in the high LET region and at lower dose than 0.5 Gy. The survivability profiles of the neurons were different in the mouse strains and ions. Memory and learning function of adult mice were studied using water maze test after localized carbon- or iron-ion irradiation to hippocampus area. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-166, 号 HIMAC-069, p. 66-67, 発行日 2004-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
