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前立腺がん細胞に対する粒子線照射後のＤＮＡ修復機構開発
https://repo.qst.go.jp/records/55250
https://repo.qst.go.jp/records/55250c374f77d-e0db-473a-ab9c-dee6531b6094
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-25 | |||||
| タイトル | ||||||
| タイトル | 前立腺がん細胞に対する粒子線照射後のＤＮＡ修復機構開発 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
杉村, 和朗
× 杉村, 和朗× 西村, 英輝× 出水, 祐介× 佐々木, 良平× 古澤, 佳也× 安藤, 興一× 杉村 和朗× 西村 英輝× 出水 祐介× 佐々木 良平× 古澤 佳也× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | DNA double strand breaks (DSBs) induced by carbon ion irradiation and DSBs repair was assessed in this study. Human prostate cancer cell line DU145 was transfected with Rad51 antisense oligonucleotides and irradiated with carbon ions. Surviving fraction and other parameters were obtained. Clonogenic assay revealed that transfection of Rad51 antisense oligonucleotides increased radiosensitivity very little in carbon ion irradiation, whereas it increased about 1.7 fold in X-irradiation. Comet assay was also performed for quantitative analysis of DSB induction and repair. There was no difference of DSB induction and repair rate after carbon ion irradiation in the cells treated with Rad51 antisense oligonucleotides and with control oligos. These results may suggest that carbon-ion-induced DSBs are difficult to be repaired by homologous recombination. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 168-169, 発行日 2002-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
