WEKO3
アイテム
重粒子線を用いた根治的不整脈治療の開発
https://repo.qst.go.jp/records/55249
https://repo.qst.go.jp/records/552490bd75f86-8ceb-4ca4-9c70-003937c3f7b9
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-25 | |||||
| タイトル | ||||||
| タイトル | 重粒子線を用いた根治的不整脈治療の開発 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
吉岡, 公一郎
× 吉岡, 公一郎× 田中, 越郎× 藤倉, 寿則× 杉尾, 芳紀× 篠崎, 芳郎× 笠原, 啓史× 石過, 孝文× 佐藤, 江利子× 盛, 英三× 古澤, 佳也× 吉岡 公一郎× 藤倉 寿則× 盛 英三× 古澤 佳也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heterogeneities in sympathetic denervation and in myocardial blood flow are thought to be substrates of lethal ventricular arrhythmia. It cannot be fully treated even by a catheter ablation. We evaluated whether heavy ion beam could be applied to anti-arrhythmic therapy. The left chest (20x20 mm) was irradiated by a single dose (90Gy) of heavy ion beam (290MeV/u carbon-12). We created chronic myocardial ischemia by injecting microspheres (15 um in diameter) into the coronary artery in four rabbits. Two weeks after making ischemia, irradiation was performed as above in two ischemia rabbits. One month after the irradiation, program-induced VT/VF were completely suppressed. In two non-irradiated ones, however, VT/VF were induced by programmed stimulation easily. These results suggest that irradiation of heavy ion beam to the subepicardial region is applicable to the anti-arrhythmic therapy due to homogenous sympathetic denervation without deterioration in local blood flow and contraction. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 166-167, 発行日 2002-04 |
|||||
| 出版者 | ||||||
| 出版者 | 放医研 | |||||
