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M-FISH analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro
https://repo.qst.go.jp/records/55244
https://repo.qst.go.jp/records/55244444590ca-2e02-4d93-bd98-4382656dbe10
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-25 | |||||
| タイトル | ||||||
| タイトル | M-FISH analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wu, Honglu
× Wu, Honglu× Durante, Marco× Furusawa, Yoshiya× George, Kerry× Kawata, Tetsuya× A, Cucinotta Francesca× ウー ホングル× 古澤 佳也× ジョージ ケリー× 川田 哲也× クシノッタ フランク |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Confluent human fibroblast cells were exposed to 6 Gy gamma-rays or 200 MeV/nucleon Fe-ions at 0.7 or 3 Gy At HIMAC. The cells were allowed to repair for 24 hours after exposure and chromosomes were collected using a premature chromosome condensation technique with calyculin-A. Chromosome aberrations were analyzed using the multicolor FISH (mFISH) technique that allows identification of both complex and truly incomplete exchanges. Results showed that both doses of the Fe ions produced higher ratios of complex to simple exchanges and lower ratio of complete to incomplete exchanges than the 6 Gy gamma-exposure. The ratios of aberration yields were similar for the two doses of Fe ions. After 0.7 Gy of Fe-ions, most complex aberrations were found to involve three or four chromosomes, indicating this is the maximum number of chromosome domains traversed by a single Fe ion track. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC 巻 2002, p. 143-144, 発行日 2003-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
