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重粒子線照射による細胞周期制御機構における特異性に関する研究
https://repo.qst.go.jp/records/55205
https://repo.qst.go.jp/records/552050aa0b193-86dd-4259-952c-b3b1301533a4
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-19 | |||||
| タイトル | ||||||
| タイトル | 重粒子線照射による細胞周期制御機構における特異性に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
井上, 俊彦
× 井上, 俊彦× 大関, 修治× 松村, 聡子× Ｘｉｎｇ, Ｓｈｕｏ× 福島, 祥子× 井上, 武宏× 古澤, 佳也× 笠井, 清美× 井上 俊彦× 大関 修治× 井上 武宏× 古澤 佳也× 笠井 清美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the differences in expression of Cdc2, CyclinB, Cdc25B and Cdc25C proteins after irradiation with gamma ray and carbon ion beams. The G2-M transition is regulated by phosphorylation / dephosphorylation of Cdc2 and its states are detected as three different migrating isoforms by western blotting method. Our analysis showed that total Cdc2 protein increased gradually following both irradiation. In the case of gamma irradiation, the slower migrating isoform (27-63% of each total protein) of Cdc2 reached the level of 3.7 times in comparison with unirradiated cells after 12 hours and then decreasd gradually. The faster migrating isoform (37-73% of each total protein) peaked at the level of 1.8 times after 30 hours and persisted at this level until 40 hours. Following irradiation with carbon ion beams, the slower isoform (51-66% of each total protein) peaked at the levels of 2 times after 12 hours and kept this level until 40 hours.The faster migrating isoform(21-31% of each total protein) reached the peak level of 2.8 times after 30 hours. The middle migrating isoform (8-18% of each total protein) reached the peak level after 12 hours. There were no significant differences in Cyclin B, Cdc25B and Cdc25C. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2001, p. 114-115, 発行日 2001-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
