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Hyperpolarized [1-13C]pyruvate MRS reveals early-phase transition of energy metabolism in multicellular spheroid tumors
https://repo.qst.go.jp/records/54911
https://repo.qst.go.jp/records/5491183366ebd-e229-4b72-8d23-af19170fb124
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-04 | |||||
| タイトル | ||||||
| タイトル | Hyperpolarized [1-13C]pyruvate MRS reveals early-phase transition of energy metabolism in multicellular spheroid tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takakusagi, Yoichi
× Takakusagi, Yoichi× Takakusagi, Kaori× Inoue, Kaori× Ichikawa, Kazuhiro× Takakusagi, Yoichi× Takakusagi, Kaori |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Most tumor cells rely on aerobic glycolysis instead of mitochondrial oxidative phosphorylation (OXPHOS) to generate energy (ATP production) for cellular activities. This distinct glucose metabolism, known as the Warburg effect, is further amplified by an organization of the cells as solid tumor tissues in vivo. However, much has remained elusive; e.g. when and how the metabolic shift is triggered during tumorigenesis. In the present study, hyperpolarized (HP) [1-13C]pyruvate MRS was employed to directly monitor the transition of energy metabolism in tiny multicellular tumor spheroids of early-phase. The HP [1-13C]pyruvate conversion to [1-13C]lactate in the smaller tumor spheroids was noninvasively monitored on an NMR spectra. | |||||
| 書誌情報 |
ISMRM 2018 proceedings p. 3720, 発行日 2018-06 |
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| 出版者 | ||||||
| 出版者 | International Society for Magnetic Resonance in Medicine | |||||
