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Monitoring effect of rapamycin on pyruvate metabolism in SCC tumor using hyperpolarized 13C-MRI
https://repo.qst.go.jp/records/54910
https://repo.qst.go.jp/records/54910e6bd4877-2cc1-4e80-99bd-3ba02cea1fca
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-04 | |||||
| タイトル | ||||||
| タイトル | Monitoring effect of rapamycin on pyruvate metabolism in SCC tumor using hyperpolarized 13C-MRI | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saito, Keita
× Saito, Keita× Matsumoto, Shingo× Takakusagi, Yoichi× Matsuo, Masayuki× Merkle, Hellmut× B. Mitchell, James× C. Krishna, Murali× Takakusagi, Yoichi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mammalian target of rapamycin (mTOR) is a protein kinase that is centrally involved in the control of cancer cell metabolism, growth, and proliferation, and therefore has become an attractive therapeutic target. Rapamycin is an inhibitor of mTOR, and inhibition of mTOR by rapamycin causes diverse effects on tumor microenvironment, such as oxygenation and energy metabolism. Such changes can serve as markers to assess tumor response to rapamycin therapy. We investigated effects of rapamycin on pyruvate metabolism to lactate in squamous cell carcinoma (SCC) xenograft using hyperpolarized 13C-MRI. Lactate dehydrogenase (LDH) is downstream protein of mTOR and expected to be affected by rapamycin treatments. | |||||
| 書誌情報 |
ISMRM 2018 proceedings p. 3069, 発行日 2018-06 |
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| 出版者 | ||||||
| 出版者 | International Society for Magnetic Resonance in Medicine | |||||
