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Synthesis of Aminoquercetin for Reducing Side Effects of Cancer Radiation Therapy
https://repo.qst.go.jp/records/54789
https://repo.qst.go.jp/records/54789b9fbaee7-5042-4453-b6d7-84d15257f9b6
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-12 | |||||
| タイトル | ||||||
| タイトル | Synthesis of Aminoquercetin for Reducing Side Effects of Cancer Radiation Therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imai, Kohei
× Imai, Kohei× Nakanishi, Ikuo× Yamamoto, Nachi× Matsumoto, Kenichiro× Fukuhara, Kiyoshi× 今井 耕平× 中西 郁夫× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation therapy is a cancer treatment in which a high-energy radiation is used to kill cancer cells. The production of hydroxyl radicals and other diffusible radicals is a principal cause of radiation damage to cancer. However, normal cells are affected by radiation therapy as well, and this accounts for the adverse side effects observed in this type of treatment. Antioxidants exhibit an ability to reduce free radicals generated by radiotherapy, and thereby decrease the effectiveness of the therapy in cancer cells. If the radical scavenging activity of antioxidants is inhibited in cancer cells, they can be used in combination with radiation cancer therapy to reduce the adverse side effects. In this study, we designed a quercetin derivative, whose radical scavenging activity was decreased under acidic conditions such as caner cells. The synthesis and radical scavenging activity of the quercetin derivative will be presented. |
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| 書誌情報 |
Free Radical Biology and Medicine 巻 100, 号 Supplement, p. S100-S100, 発行日 2016-11 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.freeradbiomed.2016.10.252 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S0891584916307237 | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S0891584916307237 | |||||
