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Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons

https://repo.qst.go.jp/records/54490
https://repo.qst.go.jp/records/54490
da450a94-810b-4e46-a71d-e27ffaeba39b
Item type 会議発表論文 / Conference Paper(1)
公開日 2014-03-06
タイトル
タイトル Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_5794
資源タイプ conference paper
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Wing, Yan Choi Viann

× Wing, Yan Choi Viann

WEKO 556561

Wing, Yan Choi Viann

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Yuen, Ping Ng Candy

× Yuen, Ping Ng Candy

WEKO 556562

Yuen, Ping Ng Candy

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Kobayashi, Alisa

× Kobayashi, Alisa

WEKO 556563

Kobayashi, Alisa

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Konishi, Teruaki

× Konishi, Teruaki

WEKO 556564

Konishi, Teruaki

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Oikawa, Masakazu

× Oikawa, Masakazu

WEKO 556565

Oikawa, Masakazu

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Han, Cheng Shuk

× Han, Cheng Shuk

WEKO 556566

Han, Cheng Shuk

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Kwan, Ngok Yu Peter

× Kwan, Ngok Yu Peter

WEKO 556567

Kwan, Ngok Yu Peter

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小林 亜利紗

× 小林 亜利紗

WEKO 556568

en 小林 亜利紗

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小西 輝昭

× 小西 輝昭

WEKO 556569

en 小西 輝昭

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及川 将一

× 及川 将一

WEKO 556570

en 及川 将一

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抄録
内容記述タイプ Abstract
内容記述 Dechorionated embryos of the zebrafish, Danio rerio, irradiated at 5 h post-fertilization (hpf) with 30 protons delivered to 10 separate positions each with an energy of 3.4 MeV from the microbeam irradiation facility (Single-Particle Irradiation System to Cell, acronym as SPICE) at the National Institute of Radiological Sciences (NIRS), developed radioadaptive response (RAR) against a subsequent challenging exposure of 2 Gy of X-ray irradiation at 10 hpf, corroborated by reduced apoptotic signals at 25 hpf revealed through terminal dUTP transferase-mediated nick end-labeling assay.
\nThe effects of the CO liberator tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the induction of RAR were examined by transferring the irradiated embryos to freshly prepared medium with the chemical at different time points after the application of the priming dose. Our results showed that transfer of irradiated embryos into media with CORM-3 at 0, 1, 2 and 3 h after application of priming exposure significantly suppressed RAR, while transfer at 5 h did not suppress RAR. This was attributed to the protection of bystander cells from the released CO, which caused less de novo synthesis of factors and thus less efficient induction of RAR. Once the factors were synthesized, RAR was induced, which would not be further affected by the application of CORM-3 introduced at 5 h after the application of the priming dose.
書誌情報 Journal of Radiation Research

巻 55, 号 S1, p. i115, 発行日 2014-02
出版者
出版者 Oxford Journals, Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 0449-3060
DOI
識別子タイプ DOI
関連識別子 doi: 10.1093/jrr/rrt165
関連サイト
識別子タイプ URI
関連識別子 http://jrr.oxfordjournals.org/cgi/content/abstract/rrt165?
関連名称 http://jrr.oxfordjournals.org/cgi/content/abstract/rrt165?
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