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Brain N-Acetylaspartate Is Increased in Mice with Hypomyelination
https://repo.qst.go.jp/records/54486
https://repo.qst.go.jp/records/54486a2127b6f-3b73-4864-970b-3457399bebeb
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-17 | |||||
| タイトル | ||||||
| タイトル | Brain N-Acetylaspartate Is Increased in Mice with Hypomyelination | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takanashi, Junichi
× Takanashi, Junichi× Saito, Shigeyoshi× Aoki, Ichio× J., Barkovich A.× Terada, H.× Ito, Y.× Inoue, K.× 高梨 潤一× 齋藤 茂芳× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | N-acetylaspartate (NAA) is a compound found predominantly in neurons and their processes, and is generally considered to be an important marker of viable, functioning neurons and axons. Many neurodegenerative disorders, therefore, exhibit a decrease of total NAA (tNAA; NAA at 2.01 ppm and N-acetylaspartylglutamate [NAAG] at 2.04 ppm, which are difficult to distinguish on clinical 1H-MRS with a 1.5 or 3.0 tesla magnet). Previous studies have shown the elevation of tNAA on 1H-MRS with 1.5 tesla magnet in Pelizaeus-Merbacher disease (PMD), a representative hypomyelination disease. In order to evaluate a hypothesis that hypomyelinating process may affect NAA and NAAG biochemical pathways, we examined myelin synthesis-deficient (msd) mouse brain, a model of PMD with a 7.0 tesla magnet and separately measured NAA and NAAG of the brains of these animals by high performance liquid chromatography (HPLC). | |||||
| 書誌情報 |
Proc. Intl. Soc. Mag. Reson. Med. 巻 19, p. 4181-4181, 発行日 2011-05 |
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