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Evaluation of Gd-DTPA Contrast Enhancement of Lung and Metastatic Tumor with Ultra-Short Echo-Time Imaging
https://repo.qst.go.jp/records/54483
https://repo.qst.go.jp/records/5448391bdfc23-10d5-43cd-bb54-76d2306c6739
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-17 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Gd-DTPA Contrast Enhancement of Lung and Metastatic Tumor with Ultra-Short Echo-Time Imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kokuryo, Daisuke
× Kokuryo, Daisuke× Aoki, Ichio× Saga, Tsuneo× 國領 大介× 青木 伊知男× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In a previous study, we administered nanoparticles containing a MR contrast agent, a fluorescence dye and an anticancer drug to successfully detect and visualize subcutaneous and deep-seated tumor in the back muscle of a mouse cancer model [1, 2]. The tumor appeared as a signal enhancement in T1-weighted MRI. As the next step, it is desired to apply the nanoparticle to lung tumors and other pulmonary disease. Imaging of the lungs is difficult because of the low proton density, short T2* and respiratory motion. However, ultra-short echo-time (UTE) imaging [3, 4] has recently been utilized to evaluate signal changes in lung parenchyma for various animal disease models [5, 6]. Moreover, quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI has been performed for pulmonary embolism and tumor in humans [7, 8]. As a preliminary step toward visible disease therapeutics using nanoparticles, the present study evaluated changes to the signal intensity in lung parenchyma and me tastatic tumor using a positive contrast agent (Gd-DTPA) and UTE imaging. | |||||
| 書誌情報 |
Proc. Intl. Soc. Mag. Reson. Med. 巻 19, p. 972-972, 発行日 2011-05 |
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