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Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR Signal: A Study Using Expression-Controlled Aquaporin4 Cells
https://repo.qst.go.jp/records/54481
https://repo.qst.go.jp/records/54481fb0d326d-3421-4ecd-bb7b-748cc315aeed
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-17 | |||||
| タイトル | ||||||
| タイトル | Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR Signal: A Study Using Expression-Controlled Aquaporin4 Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Obata, Takayuki
× Obata, Takayuki× Kershaw, Jeffrey× Kuroiwa, Daigo× Shibata, Sayaka× Yoichiro, Abe× Yasui, Masato× Aoki, Ichio× 小畠 隆行× Ｋｅｒｓｈａｗ Ｊｅｆｆｒｅｙ× 黒岩 大悟× 柴田 さやか× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Diffusion-weighted magnetic resonance imaging (DWI) plays an important role in diagnosing diseases such as brain infarction and cancer. Although it is understood that signal attenuation is due to the diffusion of water molecules, a reliable quantitative signal model relating tissue parameters and signal contrast remains to be established. Cell membrane water permeability (CMP) is one factor that may affect DWI signal contrast. Aquaporin4 (AQP4) is a channel located in the cell membrane that is known to facilitate water exchange and therefore affect CMP and perhaps DWI contrast. In this study, we performed multi-b-value and multi-diffusion-time DWI on AQP4-nonexpressed (noAQ) and AQP4-expressed (AQ) cells to investigate the effect that CMP has on diffusion-weighted magnetic resonance signal. | |||||
| 書誌情報 |
Proc. Intl. Soc. Mag. Reson. Med. 巻 20, p. 1830-1830, 発行日 2012-05 |
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