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Evaluation of Lung Metastatic Tumor Using Dextran-DTPA-Mn Nanoprobes with Ultra-Short Echo-Time Imaging
https://repo.qst.go.jp/records/54480
https://repo.qst.go.jp/records/54480a24367af-5e9c-4494-84c6-46d57959bfb6
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-17 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Lung Metastatic Tumor Using Dextran-DTPA-Mn Nanoprobes with Ultra-Short Echo-Time Imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kokuryo, Daisuke
× Kokuryo, Daisuke× Jo, Jun-ichiro× Saga, Tsuneo× Aoki, Ichio× 國領 大介× 城 潤一郎× 佐賀 恒夫× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ultra-short echo-time (UTE) imaging [1, 2] has recently been utilized to evaluate signal changes in lung parenchyma for various animal disease models [3, 4]. In addition, quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI has been performed for pulmonary embolism and tumor in humans [5, 6]. In a previous study, we reported that the signal intensity of UTE images in lung parenchyma and liver metastasis increased after conventional MR contrast agent administration [7]. Our group has also developed a multifunctional nanoprobe containing a positive MR contrast agent, a fluorescence dye and an anticancer drug, and succeeded in imaging drug delivery to subcutaneous and deep-seated tumors [8, 9]. As the next step, we applied the nanoprobes to lung tumors and other pulmonary diseases. In the present study, the signal changes in lung parenchyma with metastatic tumor after administration of nanoprobes containing manganese contrast agent were evaluated using UTE imaging. | |||||
| 書誌情報 |
Proc. Intl. Soc. Mag. Reson. Med. 巻 20, p. 1656-1656, 発行日 2012-05 |
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