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Combination of Carbon-ion Irradiation and Immunotherapy in Mouse Models
https://repo.qst.go.jp/records/54468
https://repo.qst.go.jp/records/54468c89b3658-6fee-43bd-9181-5c3e49dd30d4
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-05 | |||||
| タイトル | ||||||
| タイトル | Combination of Carbon-ion Irradiation and Immunotherapy in Mouse Models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimokawa, Takashi
× Shimokawa, Takashi× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Carbon-ion (C-ion) radiotherapy (RT) is an advanced radiotherapy effective against tumors that are resistant to conventional radiotherapy. C-ion RT can provide better results, especially local control, due to its biological properties and excellent dose distribution. However, metastasis control is an important issue that needs to be resolved to improve C-ion RT, similar to other types of cancer treatment. It is known that C-ion irradiation tends to prevent metastasis and metastasis-related behaviors, such as invasion and migration, in in vitro and in vivo assays. However, the underlying mechanisms are still not clearly understood. Our goal is to identify an optimal combination therapy to use with C-ion RT to prevent distant metastasis. In this study, we evaluated a type of immunotherapy, dendritic cells (DCs) immunotherapy, in combination with C-ion RT. We established mouse metastasis models using three mouse cancer cell lines and two mouse strains. Under conditions where there were no significant effects on the growth of the primary implanted tumor by the treatments, the number of lung metastases was significantly decreased by the combined therapy, but not by C-ion irradiation or DC injection alone. Additionally, the combined therapy suppressed pre-metastatic changes in the lungs. These results clearly indicated that the combination therapy was effective for repressing metastasis. |
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| 書誌情報 |
NIRS＆MedAustron Joint Symposium on Carbon Ion Radiotherapy p. 168-175, 発行日 2013-12 |
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