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The Oxygen Effect in Carbon Ion Radiotherapy
https://repo.qst.go.jp/records/54421
https://repo.qst.go.jp/records/54421817e52a1-b37f-4610-b8e2-02b8bc71ac80
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-10 | |||||
| タイトル | ||||||
| タイトル | The Oxygen Effect in Carbon Ion Radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
平山, 亮一
× 平山, 亮一× 鵜澤, 玲子× 松本, 孔貴× 金子, 由美子× 尾崎, 匡邦× 山下, 慶× 李, 惠子× 古澤, 佳也× 平山 亮一× 鵜澤 玲子× 松本 孔貴× 金子 由美子× 尾崎 匡邦× 山下 慶× 李 惠子× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We measured the RBE (relative biological effectiveness) and OER (oxygen enhancement ratio) and evaluated their correlations with the cell survival within implanted solid tumors following exposure to 290 MeV/nucleon clinical carbon-ion beams. SCCVII (squamous cell carcinoma) cells were transplanted into the right hind legs of syngeneic C3H/He male mice. Irradiation with either carbon-ion beams with a 6-cm spread-out Bragg peak (SOBP) or X-rays was delivered to tumors 5mm or smaller in diameter. We used two different oxygen conditions for the irradiated tumors. Hypoxic or normoxic conditions in tumors were produced by clamping the leg to stop the blood flow or by leaving the leg unclamped. After irradiation, single-cell suspensions were prepared from excised and trypsinized tumors, and were used for in vivo-in vitro colony formation assays to obtain cell survival curves. The OER value was 1.87 after X-irradiation. The OER values (1.20 ~ 1.52) of carbon-ion irradiated samples were smaller than those of X-ray irradiated samples. However, no significant changes of the OER at the proximal, middle or distal positions within the SOBP carbon-ion beams were observed. To conclude, we found that the OER values changed little with increasing LET within the SOBP carbon-ion beams. Therefore, the OERs within the SOBP carbon-ion beams can be considered to be constant values in the patient treatment plan. | |||||
| 書誌情報 |
NIRS & MedAustron Joint Symposium on Carbon Ion Radiotherapy p. 77-84, 発行日 2013-11 |
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