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Carbon Ion Radiotherapy for Prostate Cancer
https://repo.qst.go.jp/records/54301
https://repo.qst.go.jp/records/54301fd06c91c-7272-48a1-9a6f-d06e5780b29b
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-11-21 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Prostate Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuji, Hiroshi
× Tsuji, Hiroshi× Okada, Tohru× Kamada, Tadashi× Tsujii, Hirohiko× 辻 比呂志× 岡田 徹× 鎌田 正× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: An up-to-date analysis of the results of hypofractionated conformal carbon ion radiotherapy (C-ion RT) for localized prostate cancer was performed to determine the normal tissue morbidity, biochemical relapse-free rate (bNED), and patient survival. Methods and Materials: Nine hundred and three prostate cancer patients who received the C-ion RT that had been established by two prior dose-escalation studies were analyzed with regard to toxicity, survival, and bNED. Results: Only 1 out of 818 patients followed up for at least 12 months developed grade 3 genitourinary toxicity, and no grade 3 or higher toxicities were observed in the rectum. The incidence of grade 2 rectum and GU morbidity were only 2.0% and 5.6%, respectively. The incidence of late toxicity in the patients treated with C-ion RT for 16 fractions was lower than that for patients who received 20 fractions. The overall bNED at 5 years was 90.9%, with only five local recurrences. The bNED of the 16-fraction C-ion RT was comparable to that of 20 fractions. The Gleason's score, T-stage, and initial PSA were significant prognostic factors for bNED, and the T-stage and initial PSA were also significant prognostic factors for the overall survival rate. C-ion RT with the established dose fractionation regimen yielded satisfactory bNED with very few local recurrences, and with minimal morbidity. Therefore, C-ion RT in 16 fractions could offer an even lower incidence of toxicities than 20 fractions, without any decrease in the biochemical control of the disease. |
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| 書誌情報 |
Proceedings of Japanease-European Joint Symposium on Ion Cancer Therapy and NIRS-KI Joint Symposium on Ion-Radiation Sciences, September 9 & 10-11, 2010 Karolinska University Hospital, Solna Stockholm, Sweden Organized by National Institute of Radiological Sciences, Japan and Karolinska Institute, Sweden 巻 NIRS-M, 号 235, p. 44-53, 発行日 2010 |
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| 出版者 | ||||||
| 出版者 | National Institute of Radiological Sciences | |||||
