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Carbon Ion Radiotherapy in a Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer
https://repo.qst.go.jp/records/54286
https://repo.qst.go.jp/records/542867bc6412b-a6b1-44ce-b295-dba501b80932
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-23 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy in a Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Baba, Masayuki
× Baba, Masayuki× Yamamoto, Naoyoshi× Nakajima, Mio× Horino, Takeshi× Yoshikawa, Kyosan× Imai, Reiko× 馬場 雅行× 山本 直敬× 中嶋 美緒× 堀野 武× 吉川 京燦× 今井 礼子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | From 1994 to 1999,we conducted a phase I/II clinical trial for patients with stage I non-small cell lung cancer(NSCLC)using carbon ion beams alone,demonstrating optimal doses of 90.0GyE in 18 fractions over 6 weeks(Protocol#9701),which led to more than 95%local control with minimal pulmonary damage.In the present study,the total dose was fixed at 72.0GyE in 9 fractions over 3 weeks(Protocol#9802),and at 52.8GyE for stage IA and 60.0GyE for stage IA and 60.0GyE for stage IB in 4 fractions in 1 week(Protocol#0001). Following this schedule, we conducted a phase II clinical trial for stage I NSCLC from 1999 to 2003. We also conducted a phase I/II single fractionation clinical trial(Protocol#0201) as a dose escalation study. The total dose was initially 28.0GyE in 2003, and it was increased to 46.0GyE in 2008. This article describes the intermediate steps. Most targets were irradiated from four oblique directions. A respiratory-gated irradiation system was used for all sessions. Local control and survival were by the Kaplan-Meier method. statistical testing,the Log-rank test was used. The local control rate for all patients(#9802 and #0001) was 91.5%,and for those with T1 and T2 tumors was 96.3% and 84.7%,respectively. while there was significant difference(P=0.0156) in the tumor control rate between patients with T1 and T2 tumors, there was no significant difference(P=0.1516) between squamous cell carcinomas and non-squamous cell carcinomas. The 5-year cause-specific survival rate was 67.0% (IA:84.4,IB:43.7), and overall survival was 45.3%(IA:53.9,IB:34.2). No adverse effects greater than grade 2 ocurred in the lungs. In a single fractionation trial, the 3-year local control rate for 117 patients was 81.9%, and the control rates for patients with T1 and T2 tumors were 84.7% and 78.0%,respectively. No adverse effects greater than grade 2 ocurred in the lungs. Carbon beam radiotherapy, an excellent new modality in terms of high QOL and ADL,was proven to be a valid alternative to surgery for stage I cancer, especially for elderly and inoperable patients. |
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| 書誌情報 |
Proceedings of Japanease-European Joint Symposium on Ion Cancer Therapy and NIRS-KI Joint Symposium on Ion-Radiation Sciences, September 9 & 10-11, 2010 Karolinska University Hospital, Solna Stockholm, Sweden Organized by National Institute of Radiological Sciences, Japan and Karolinska Institute, Sweden 巻 NIRS-M, 号 235, p. 63-73, 発行日 2010 |
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| 出版者 | ||||||
| 出版者 | National Institute of Radiological Sciences | |||||
