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Radical-Scavenging Activity of Biosynthetic Precursors of Vitamin E and Their Derivatives
https://repo.qst.go.jp/records/54221
https://repo.qst.go.jp/records/54221750da776-6c94-40a8-8ff6-95fd74784d00
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-06-16 | |||||
| タイトル | ||||||
| タイトル | Radical-Scavenging Activity of Biosynthetic Precursors of Vitamin E and Their Derivatives | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Uto, Yoshihiro× Ohkubo, Kei× Matsumoto, Kenichiro× Hori, Hitoshi× Fukuhara, Kiyoshi× Okuda, Haruhiro× Ikota, Nobuo× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× 中西 郁夫× 松本 謙一郎× 小澤 俊彦× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is known that 2-methyl-6-phytylhydroquinone (2-MePHQ) and 2,3-dimethyl-6-phytylhydroquinone (2,3-Me2PHQ) are formed as precursors in the biosynthetic process of vitamin E. However, very little is known about the antioxidative activity of these vitamin E precursors. Thus, we determined the scavenging rate constants of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 2-MePHQ, 2,3-Me2PHQ, and their synthetic analogues, 2,5-dimethyl-6-phytylhydroquinone (2,5-Me2PHQ) and 2,3,5-trimethyl-6-phytylhydroquinone (2,3,5-Me3PHQ) in deaerated ethanol at 298 K using the stopped-flow technique. 2,3,5-Me3PHQ and 2,3-Me2PHQ, which have a methyl group at the C-3 position, showed a stronger DPPH radical-scavenging activity than alpha-tocopherol. The mechanism of the DPPH radical-scavenging reaction by the hydroquinones will also be discussed based on the kinetic and theoretical results obtained in this study. | |||||
| 書誌情報 |
Free Radical Biology and Medicine 巻 47, 号 Supplement 1, p. S191-S191, 発行日 2009-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0891-5849 | |||||
