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FGF2 expression change as an acute radiotherapy responsive marker in sequential biopsy samples from cervical cancer patients during fractionated radiotherapy.
https://repo.qst.go.jp/records/54179
https://repo.qst.go.jp/records/541799ac5959e-e02e-450d-896d-8ca805631558
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-11-11 | |||||
| タイトル | ||||||
| タイトル | FGF2 expression change as an acute radiotherapy responsive marker in sequential biopsy samples from cervical cancer patients during fractionated radiotherapy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iwakawa, Mayumi
× Iwakawa, Mayumi× Nakawatari, Miyako× Imadome, Kaori× Ohno, Tatsuya× Kato, Shingo× Nakamura, Etsuko× Sakai, Minako× Ohkubo, Yu× Tamaki, Tomoaki× Imai, Takashi× 岩川 眞由美× 中渡 美也子× 今留 香織× 大野 達也× 加藤 眞吾× 中村 悦子× 酒井 美奈子× 大久保 悠× 田巻 倫明× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose Tumor microenvironment possesses extreamly important role for tumor progression and metastasis. Cytokines have autocrine and paracrine functions, and they are also secreted by normal and cancerous cells. Herewith we investigated an indicator for the efficacy of radiotherapy in cervical cancers (CC) using microarray analysis and immunohistochemical analysis. Patients and methods One hundred and four patients with CC were recruited and divided into two groups (research set: n =35, and validation set: n =69). Microarray analysis was performed in research set and further immunohistochemical analysis (IHA) was performed for all patients to detect candidate radioresponsive markers using pre-radiotherapy and mid-radiotherapy biopsy samples, which were taken one week after initiation of radiotherapy. Results FGF2 in tumor cells (FGF2–T) significantly increased in midtreatment samples compared with pretreatment samples in research set of patients, and the ratio change of FGF2-T was significantly related with better prognosis. This evidence was confirmed in validation set. Next using all 104 patimets we found IHA positive FGF2 in stromal cells (FGF2-S) in 85 patients, and the radiotherapy-induced increase of FGF-S in 23 patients. Though positive FGF2-S in pretreatment samples was significantly related with increased expression change of VEGF, it was not related with poor prognosis. Conclusion Radiation causes severing the normal or cancerous associations with adjacent cells and changes the extracellular matrix environment. Therefore, we need to investigate not only pretreatment status of tumors, but also modified tumor structures during fractionated radiotherapy. In this study, we found FGF2-T expression change as a monitoring marker for the effectiveness of radiotherapy, and found the relationship between FGF2-S in pretreatment status and VEGF expression change in a subgroup of patients. |
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| 書誌情報 |
Cancer Microenvironment 巻 2, 号 1, p. 116-116, 発行日 2009-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1875-2292 | |||||
