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Genes Activated by Low Dose Radiation
https://repo.qst.go.jp/records/54040
https://repo.qst.go.jp/records/54040aa2f800a-c386-4511-a798-d47858387574
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-06 | |||||
| タイトル | ||||||
| タイトル | Genes Activated by Low Dose Radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nenoi, Mitsuru
× Nenoi, Mitsuru× Taki, Keiko× Bing, Wang× Nakajima, Tetsuo× 根井 充× 瀧 景子× 王 冰× 中島 徹夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The major risk caused by radiation is cancer. The cancer incidence has been estimated based on the epidemiological studies on atomic bomb survivors in Hiroshima and Nagasaki, which are the cases of high dose-rate exposure over intermediate dose ranges. The cancer risk due to low-dose-rate radiation has not been well established, because sufficient epidemiological data have not been available. It is generally considered that the animal study is an alternative approach to this issue if it is combined with the study on mechanism of radiation effects to extrapolate the animal data to humans. A large-scale study of the biological effect of continuous low dose-rate irradiation has been performed at Institute for Environmental Sciences (IES) in Japan. Assessment of low-dose-rate radiation effect is a difficult issue, because a long-term experiment using a lot of animals in specific pathogen free (SPF) conditions is required. Continuous irradiation of 4,000 SPF mice for 400-days was carried out at IES, and the result was published by Tanaka in 2003 (Fig.2). He reported that the life spans of mice irradiated at the dose-rate of 16,000 nGy/min were significantly shortened, but not at the dose-rate of 40 nGy/min. A significant life span-shortening in female mice irradiated at 800 nGy/ min was observed. In order to investigate the molecular mechanisms for the life span-shortening caused by low dose-rate irradiation, we examined gene expression profiles at the time of termination of continuous irradiation. Figure 3 shows the dose-rate range used in the life span study at IES in comparison with various natural radiation levels. The lowest dose-rate level is 20 times higher than the natural radiation level in Japan, and close to the cosmic radiation at 12,000 elevation and natural radiation level in Ramsar in Iran, which is known as one of the high background radiation areas. The middle level is comparable to the dose-rate that the astronauts working inside or outside the space station are exposed to. The highest level is 20 times higher than this level. The pathological analysis of the mice used in the life span study at IES was completely recently, and it was reported by Tanaka that the observed life spans-shortening was due to early death from a variety of neoplasms and not from increased incidence of specific neoplasms. This result suggests that effects of the low-dose-rate radiation may be somewhat ubiquitous over various organs. |
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| 書誌情報 |
Proceedings of NIRS International Symposium on the Effects of Low Dose Radiation 巻 NIRS-M-211, p. 38-43, 発行日 2008-03 |
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| 出版者 | ||||||
| 出版者 | National Institute of Radiological Sciences | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-4-9389-8751 | |||||
