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Phase I/II trial of carbon-ion therapy for patients with locally recurrent rectal cancer
https://repo.qst.go.jp/records/53626
https://repo.qst.go.jp/records/536266503c602-17c4-4227-be6e-6f8fd3f577ed
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-01-04 | |||||
| タイトル | ||||||
| タイトル | Phase I/II trial of carbon-ion therapy for patients with locally recurrent rectal cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Kamada, Tadashi× Yasuda, Shigeo× Tsujii, Hirohiko× Ochiai, Takenori× 山田 滋× 鎌田 正× 安田 茂雄× 辻井 博彦× 落合 武徳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The rate of local recurrence(LR) for rectal cancer ranges from 10 to 40%. Most patients are referred for radiotherapy. Radiotherapy is generally considered palliative treatment. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients locally recurrent rectal cancer. Methods: Between April 2001 and September 2003, 33 lesions at 32 patients were enrolled onto this study. Criteria for trial eligibility were confirmation of locally recurrent rectal cancers without distant metastases by CT, MRI and PET findings and ECOG performance score 0,1,2. Contraindications for trial entry included pelvic bone destruction or infiltration into the bladder. Carbon beams of 290, 350 and 400 MeV/nucleon energy were generated in the HIMAC synchrotron. The dose was determined as 67.2GyE and escalated to 70.4GyE,73.6GyE. Of the 32 eligible patients, 16 were male and 16 female. Median age was 62.8 years. The predominant sites of relapse were 13 presacral, 11 lymph nodes. Toxicity on organs were assessed according to the NCI-CTC and RTOG/EOTRC classification. Tumor response was defined by the RESIST scoring system. Local recurrence was defined in terms of lesions occurring in the tumor bed. Survival curves were estimated by the Kaplan and Meier method. Results: Ten patients received radiation dose at 67.2GyE, fourteen at 70.4GyE and nine at 73.6GyE. All toxicities in the 33 lesions at 32 patients were relatively few and mild in these patients. No grade 3 to 5 acute and late toxicity was observed. Tumor response was evaluated in 33 lesions patients. CR was observed in 5 lesions and PR in 11. The local control rates in 33 lesions are 84.9% at one year and 81.5% at two years. Local control rates at one year were 70% at 67.2GyE, 85% at 70.4GyE and 100% at 73.6GyE. The one and two year overall survival rate were 90.3% and 72.0% respectively. In the literature, the reported two-year survival rates for locally recurrent rectal cancer treated with radiation were 20 to 40%. Conclusions: : Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. | |||||
| 書誌情報 |
Journal of Clinical Oncology 巻 23, 号 16S, p. 3638, 発行日 2005-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0732-183X | |||||
