WEKO3
アイテム
Different apoptosis and reproductive death on cells in UV-A and UV-B region
https://repo.qst.go.jp/records/53478
https://repo.qst.go.jp/records/534782d2c1121-bcbc-4eab-8053-b7d7533ec021
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-01-19 | |||||
| タイトル | ||||||
| タイトル | Different apoptosis and reproductive death on cells in UV-A and UV-B region | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Furusawa, Yoshiya
× Furusawa, Yoshiya× Aoki, Mizuho× 古澤 佳也× 青木 瑞穂 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We measured action spectra for induction of apoptosis and reproductive cell death in mouse L5178Y cells. The cells were exposed to different wavelengths of monochromatic UV-A and –B light. The frequencies of apoptosis induction and reproductive cell death were determined by counting cells with chromatin condensation and by an agarose colony formation assay, respectively. The measured action spectra for the two end-points were similar to each other. The sensitivity decreased steeply with an increase of wavelength in UV-B region, but showed no further decrement in UV-A region. The action spectra were slightly steeper than that for the MED, and were much more similar to the light-absorption spectrum of DNA in UV-B region. On the other hand, the spectra for both endpoints were more close to the MED, but not DNA in UV-A region. The difference between the measured spectra and that for MED may have been caused by the absorption of the light by the skin. Differences in the time course and morphological difference of apoptosis were found between UV-B and UV-A region. These results suggest that although DNA damage induced by UV-B light can trigger apoptosis, or lead to reproductive cell death, other damage (membrane, protein and so on) may excessively trigger those effects in UV-A region. | |||||
| 書誌情報 |
Photomedicine and Photobiology 巻 26, p. 13-14, 発行日 2004 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-232X | |||||
