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LET and Ion-species Dependence for Mutation Induction and Mutation Spectrum on hprt Locus in Normal Human Fibroblasts.
https://repo.qst.go.jp/records/53477
https://repo.qst.go.jp/records/534776ea98733-0f08-417f-b03d-2c500b7a6728
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-01-17 | |||||
| タイトル | ||||||
| タイトル | LET and Ion-species Dependence for Mutation Induction and Mutation Spectrum on hprt Locus in Normal Human Fibroblasts. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuruoka, Chizuru
× Tsuruoka, Chizuru× Suzuki, Masao× Fujitaka, Kazunobu× 鶴岡 千鶴× 鈴木 雅雄× 藤高 和信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have been studying LET and ion species dependence of RBE in mutation frequency and mutation spectrum of deletion pattern of exons in hprt locus. Normal human skin fibroblasts were irradiated with heavy-ion beams, such as carbon- (290 MeV/u and 135 MeV/u), neon- (230 MeV/u and 400 MeV/u), silicon- (490 MeV/u) and iron- (500 MeV/u) ion beams, generated by Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS). Mutation induction in hprt locus was detected to measure 6-thioguanine resistant colonies and deletion spectrum of exons was analyzed by multiplex PCR. The LET-RBE curves of mutation induction for carbon- and neon-ion beams showed a peak around 75 keV/microm and 155 keV/microm, respectively. On the other hand, there observed no clear peak for silicon-ion beams. The deletion spectrum of exons was different in induced mutants among different ion species. These results suggested that quantitative and qualitative difference in mutation occurred when using different ion species even if similar LET values. | |||||
| 書誌情報 |
Biological Sciences in Space 巻 18, 号 3, p. 188-189, 発行日 2004-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9201 | |||||
