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LET and ion-species dependence for cell killing and mutation induction in normal human fibroblasts
https://repo.qst.go.jp/records/53316
https://repo.qst.go.jp/records/533163db5689a-b28f-42fa-acfb-4a9965242f9a
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-03-04 | |||||
| タイトル | ||||||
| タイトル | LET and ion-species dependence for cell killing and mutation induction in normal human fibroblasts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuruoka, Chizuru
× Tsuruoka, Chizuru× Suzuki, Masao× Fujitaka, Kazunobu× 鶴岡 千鶴× 鈴木 雅雄× 藤高 和信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have been studying LET and ion species dependence of RBE values in cell killing and mutation induction. Normal human skin fibroblasts were irradiated with heavy-ion beams such as carbon (290MeV/u and 135MeV/u), neon (230MeV/u and 400MeV/u), silicon (490MeV/u) and iron (500MeV/u) ion beams, generated by Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS). Cell killing effect was detected as reproductive cell death using a colony formation assay. Mutation induction in hprt locus was detected to measure 6-thioguanine resistant colonies. The RBE-LET curves of cell killing and mutation induction were different each ion beam. So, we plotted RBE for cell killing and mutation induction as function of Z*2/B2 instead of LET. RBE-Z*2/B2 curves of cell killing indicated that the discrepancy of RBE-LET curves was reconciled each ion species. But RBE-Z*2/B2 curves of mutation induction didn't corresponded between carbon- and silicon-ion beams. These results suggested that different biological endpoints may be suitable for different physical parameter, which represent the track structure of energy deposition of ion beams. | |||||
| 書誌情報 |
Biological Sciences in Space 巻 17, 号 3, p. 185-186, 発行日 2003-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9201 | |||||
