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Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells
https://repo.qst.go.jp/records/53314
https://repo.qst.go.jp/records/533141c3b6c3c-9e55-468b-a91b-32a8aa71e9ba
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-03-04 | |||||
| タイトル | ||||||
| タイトル | Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Masao
× Suzuki, Masao× Zhou, Hongning× K, Hei Tom× Tsuruoka, Chizuru× Fujitaka, Kazunobu× 鈴木 雅雄× 鶴岡 千鶴× 藤高 和信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report here a bystander effect in chromosomal damage using He-ion microbeam. Human-hamster hybrid cells were irradiated with a precision He-ion microbeam generated by the Columbia microbeam system. When 20% of the cells were exposed to single He ion, the incidence of cells with chromatid-type breaks detected with the PCC technique was covered wide range from 0 to 6 breaks per cell. In contrast, the distribution showed a mixed two-peak pattern, such as non-exposed and all-cell exposed patterns, under the condition of assuming no bystander effect by treating with an effective inhibitor of cell-cell communication. These findings provide clear evidence that single He-ion irradiated cells can induce bystander chromosomal alterations in neighboring cells not directly hit by He ion. | |||||
| 書誌情報 |
Biological Sciences in Space 巻 17, 号 3, p. 251-252, 発行日 2003-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9201 | |||||
