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  1. 原著論文

Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.

https://repo.qst.go.jp/records/49614
https://repo.qst.go.jp/records/49614
27b72867-b2be-4b33-8095-27019bc0ad35
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-11-19
タイトル
タイトル Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Nuryadi, Endang

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WEKO 745940

Nuryadi, Endang

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Sasaki, Yasushi

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WEKO 745941

Sasaki, Yasushi

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Hagiwara, Yoshihiko

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WEKO 745942

Hagiwara, Yoshihiko

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Bunga Mayang Permata, Tiara

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WEKO 745943

Bunga Mayang Permata, Tiara

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Sato, Hiro

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WEKO 745944

Sato, Hiro

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Komatsu, Shuichiro

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WEKO 745945

Komatsu, Shuichiro

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Yoshimoto, Yuya

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WEKO 745946

Yoshimoto, Yuya

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Murata, Kazutoshi

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WEKO 745947

Murata, Kazutoshi

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Ando, Ken

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WEKO 745948

Ando, Ken

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Kubo, Nobuteru

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WEKO 745949

Kubo, Nobuteru

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Okonogi, Noriyuki

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WEKO 745950

Okonogi, Noriyuki

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Takakusagi, Yosuke

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WEKO 745951

Takakusagi, Yosuke

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Adachi, Akiko

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WEKO 745952

Adachi, Akiko

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Iwanaga, Mototaro

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Iwanaga, Mototaro

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Tsuchida, Keisuke

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WEKO 745954

Tsuchida, Keisuke

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Tamaki, Tomoaki

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WEKO 745955

Tamaki, Tomoaki

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Shin-Ei, Noda

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WEKO 745956

Shin-Ei, Noda

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Hirota, Yuka

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WEKO 745957

Hirota, Yuka

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Shibata, Atsushi

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WEKO 745958

Shibata, Atsushi

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Ohno, Tatsuya

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WEKO 745959

Ohno, Tatsuya

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Tokino, Takashi

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WEKO 745960

Tokino, Takashi

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Oike, Takahiro

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WEKO 745961

Oike, Takahiro

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Nakano, Takashi

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WEKO 745962

Nakano, Takashi

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Yoshimoto, Yuya

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WEKO 745963

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Murata, Kazutoshi

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WEKO 745964

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Ando, Ken

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WEKO 745965

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Kubo, Nobuteru

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WEKO 745966

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Okonogi, Noriyuki

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WEKO 745967

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Tamaki, Tomoaki

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WEKO 745968

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Shibata, Atsushi

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WEKO 745969

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Ohno, Tatsuya

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Nakano, Takashi

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抄録
内容記述タイプ Abstract
内容記述 Radiotherapy is an essential component of cancer therapy. Despite advances in cancer genomics, the mutation signatures of radioresistant tumors have not yet been fully elucidated. To address this issue, we analyzed a unique set of clinical specimens from a uterine cervical cancer that repeatedly locally recurred after multiple rounds of radiotherapy. Exon sequencing of 409 cancer-related genes in the treatment-naïve tumor and the tumors that recurred after initial and secondary radiotherapy identified (i) activating mutations in and , and putative inactivating mutations in , as trunk mutation signatures that persisted over the clinical course; and (ii) mutations in , , and as acquired mutation signatures observed only in recurrent tumors after radiotherapy. Comprehensive mining of published genomics data pertaining to radiosensitivity revealed that simultaneous mutations in and , which have not been described previously in uterine cervical cancer, are associated with cancer cell radioresistance. The association between this mutation signature and radioresistance was validated by isogenic cell-based experiments. These results provide proof-of-principle for the analytical pipeline employed in this study, which explores clinically relevant mutation signatures for radioresistance, and demonstrate that this approach is worth pursuing with larger cohorts in the future.
書誌情報 Oncotarget

巻 9, 号 66, p. 32642-32652, 発行日 2018-08
出版者
出版者 Inpact Journals
ISSN
収録物識別子タイプ ISSN
収録物識別子 1949-2553
PubMed番号
識別子タイプ PMID
関連識別子 30220971
DOI
識別子タイプ DOI
関連識別子 10.18632/oncotarget.25982
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