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Neutron-Induced Rat Mammary Carcinomas Are Mainly of Luminal Subtype and Have Multiple Copy Number Aberrations
https://repo.qst.go.jp/records/49539
https://repo.qst.go.jp/records/4953941826226-4fbf-4d25-b7df-dc957cddabb2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-04 | |||||
| タイトル | ||||||
| タイトル | Neutron-Induced Rat Mammary Carcinomas Are Mainly of Luminal Subtype and Have Multiple Copy Number Aberrations | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moriyama, Hitomi
× Moriyama, Hitomi× Daino, Kazuhiro× Imaoka, Tatsuhiko× Nishimura, Mayumi× Nishimura, Yukiko× Takabatake, Masaru× Morioka, Takamitsu× Fukushi, Masahiro× Shimada, Yoshiya× Kakinuma, Shizuko× Moriyama, Hitomi× Daino, Kazuhiro× Imaoka, Tatsuhiko× Nishimura, Mayumi× Nishimura, Yukiko× Takabatake, Masaru× Morioka, Takamitsu× FUkushi, Masahiro× Shimada, Yoshiya× Kakinuma, Shizuko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: Neutrons are used as a type of high linear energy transfer (LET) radiation and they have stronger carcinogenic effects compared to low LET radiation. We sought to clarify the features of mammary carcinomas for which the incidence increases when these were exposed to neutron radiation. Materials and Methods: We compared mammary carcinomas from female Sprague-Dawley rats irradiated at 7 weeks of age with 0.485 Gy neutron beams or 0.5 Gy γ rays, with carcinomas of non-irradiated rats. Tumors were classified into luminal and non-luminal subtypes based on immunohistochemistry, while their copy number aberrations were determined using microarrays. Results: Neutrons and γ rays significantly increased the incidence of luminal carcinomas. The carcinomas in the three groups contained multiple aberrations affecting 46 genes for which mutations have been reported in human breast cancer. Conclusion: Neutrons and γ rays increase the incidence of luminal mammary carcinoma in rats, probably via genetic aberrations similar to those found in human breast cancer patients. |
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| 書誌情報 |
Anticancer Research 巻 39, 号 3, p. 1135-1142, 発行日 2019-03 |
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| 出版者 | ||||||
| 出版者 | International Institute of Anticancer Research (IIAR) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30842142 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21873/anticanres.13222 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ar.iiarjournals.org/content/39/3/1135.figures-only | |||||
