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Antimetastatic Effects of Carbon-Ion Beams on Malignant Melanomas
https://repo.qst.go.jp/records/49498
https://repo.qst.go.jp/records/49498417b5202-b81e-4053-b94c-050e0df99ea8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-31 | |||||
| タイトル | ||||||
| タイトル | Antimetastatic Effects of Carbon-Ion Beams on Malignant Melanomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Furusawa, Yoshiya× Uzawa, Akiko× Hirayama, Ryoichi× Koike, Sachiko× Ando, Koichi× Tsuboi, Koji× Sakurai, Hideyuki× Matsumoto, Yoshitaka× Furusawa, Yoshiya× Uzawa, Akiko× Hirayama, Ryoichi× Koike, Sachiko× Ando, Koichi× Tsuboi, Koji× Sakurai, Hideyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The goal of this work was to clarify the effect of carbon-ion beams on reduction of the metastatic potential of malignant melanoma using in vitro and in vivo techniques. We utilized a 290 MeV/u carbon beam with a 6-cm spread-out Bragg-peak (SOBP), 137Cs c rays or 200 kVp X rays for irradiation, and in vitro murine melanoma B16/BL6 cells that were implanted into C57BL/6J mice. The metastatic abilities (migration, invasion and adhesion) were suppressed by carbon ion treatment at all doses that were tested, whereas invasion and migration tended to increase after X-ray irradiation at low dose. Biological effects of carbon ions increased with linear energy transfer (LET) for both cell killing and metastatic abilities, although the effects were more pro- nounced for migration and invasion. mRNA expression of E- cadherin was significantly downregulated with low-dose photon exposures, but increased with dose or LET. Expres- sion of Mel-CAM and L1-CAM was upregulated after low- dose photon exposure, but decreased with dose, especially after carbon-ion treatment. Conversely, these molecules showed a reversal in expression changes, especially after low-dose photon exposure. Cell-cell adhesion may be an important contributor to the antimetastatic effect of carbon ion treatment. The number of lung metastases after local tumor irradiation significantly decreased with increased dose and LET, with carbon ions being more effective than c rays. Integrating dose-response curves to examine the relationship between cell killing and lung metastasis clearly showed that carbon ions inhibit lung metastasis more efficiently than photons at the iso-effective level of cell killing. Thus, carbon ions were more effective than photon beams, not only at killing tumor cells, but also at inhibiting metastatic spread caused by tumor cells that survived irradiation. | |||||
| 書誌情報 |
Radiation Research 巻 190, 号 4, p. 412-423, 発行日 2018-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30040045 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RR15075.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.rrjournal.org/doi/pdf/10.1667/RR15075.1 | |||||
