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Estimation of RBE Values for Carbon-Ion Beams in the wide Dose Range using Multicellular Spheroids
https://repo.qst.go.jp/records/49495
https://repo.qst.go.jp/records/4949562a6b813-5101-4d85-b49b-64fdb087f525
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-02 | |||||
| タイトル | ||||||
| タイトル | Estimation of RBE Values for Carbon-Ion Beams in the wide Dose Range using Multicellular Spheroids | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Furusawa, Yoshiya× Mizuho, Nakano-Aoki× Matsufuji, Naruhiro× Hirayama, Ryoichi× Kanai, Tatsuaki× Ando, Koichi× Sakurai, Hideyuki× Furusawa, Yoshiya× Matsufuji, Naruhiro× Hirayama, Ryoichi× Kanai, Tatsuaki× Ando, Koichi× Sakurai, Hideyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hypofractionated carbon-ion therapy has been applied to treatment of several tumors. In this case, relative biological effectiveness (RBE) at high dose region must be considered, however, the RBE calculated physically has been not verified biologically. In this study, spheroid technique was adopted to estimate RBE in wide dose range. Cells were irradiated with X-rays and heavy-ions with LET of 13, 35, 100 and 300 keV/μm with monolayer and spheroid condition. Surviving fractions in wide dose range (0-15 Gy) were obtained to combined monolayer with spheroid survival data. The linear- quadratic and multi-target single-hit equation fitted well in survival data at low dose, and high dose region, respectively. A multi-process equation showed best fitting for survival data in wide dose range. RBE values of heavy-ions could be estimated by combination of monolayer and spheroid data. The values converged at 1.1-1.4 and varied by LET values at high and low dose region, respectively. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 183, 号 1-2, p. 45-49, 発行日 2019-01 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/rpd/ncy269 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/rpd/advance-article/doi/10.1093/rpd/ncy269/5281265?searchresult=1 | |||||
