WEKO3
アイテム
Evidence of Local Concentration of α-Particles from 211At-Labeled Antibodies in Liver Metastasis Tissue
https://repo.qst.go.jp/records/49494
https://repo.qst.go.jp/records/4949481f2b1dd-3214-4c86-8956-d8d71feb1634
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-09 | |||||
| タイトル | ||||||
| タイトル | Evidence of Local Concentration of α-Particles from 211At-Labeled Antibodies in Liver Metastasis Tissue | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kodaira, Satoshi
× Kodaira, Satoshi× Morokoshi, Yukie× Keiko Li, Huizi× Konishi, Teruaki× Kurano, Mieko× Hasegawa, Sumitaka× Kodaira, Satoshi× Morokoshi, Yukie× Li, Huizi× Konishi, Teruaki× Kurano, Mieko× Hasegawa, Sumitaka |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated the local concentration of α-particles from 211At-labeled trastuzumab antibodies against HER2 (human epidermal growth factor receptor type2) antigens in liver metastasis tissue of mice. Mice carrying metastatic cancer in their liver were injected with 211At-agent. After 12 hours, the liver was removed and sliced, and two tissue samples of liver tissues without lesions and one containing metastatic lesions were mounted on the CR-39 plastic nuclear track detector. Microscope images of the tissues on CR-39 were acquired. After irradiation for 31 hours, the tissues were removed from CR-39. A microscope image of α-particle tracks on CR-39 was acquired after chemical etching. The positions of each tissue sample and the emitted α-particle tracks were adjusted to the same coordinates. The positional distribution of α-particle tracks emitted from 211At was consistent within the tissue. The α-particle tracks were mainly allocated in the tumor region of the tissue. The absorbed dose in individual cells segmented by 10 µm intervals was obtained by the spectroscopic analysis of the LET (linear energy transfer) spectrum. The concentration efficiency, the track density ratio of α-particle tracks in the necrotized tissue, which was the tumor region, to the normal tissue, was found to be 6.0 ± 0.2. In the tumor region, the high LET α-particles deposited a large enough dose to cause lethal damage to the cancer cells. The total absorbed dose ranged from 1 to 7 Gy with a peak at around 2 Gy, which would correspond to 2-3 times higher biologically equivalent dose because of the high RBE of the α-particles emitted from 211At. | |||||
| 書誌情報 |
Journal of nuclear medicine 巻 60, 号 4, p. 497-501, 発行日 2018-10 |
|||||
| 出版者 | ||||||
| 出版者 | Society of Nuclear Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0161-5505 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2967/jnumed.118.216853 | |||||
