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A Quantitative Analysis of Carbon-Ion Beam-Induced Reactive Oxygen Species and RedOx Reactions
https://repo.qst.go.jp/records/49452
https://repo.qst.go.jp/records/49452f6f72a92-666a-44c4-9d6c-1cb6ad197a0a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Matsumoto.K.2019.J.Clin.Biochem.Nutr.65.1-7.pdf (552.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-12-14 | |||||
| タイトル | ||||||
| タイトル | A Quantitative Analysis of Carbon-Ion Beam-Induced Reactive Oxygen Species and RedOx Reactions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Nyui, Minako× Ueno, Megumi× Ogawa, Yukihiro× Nakanishi, Ikuo× Matsumoto, Kenichiro× Nyui, Minako× Ueno, Megumi× Ogawa, Yukihiro× Nakanishi, Ikuo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The amounts of reactive oxygen species generated in aqueous samples by irradiation with X-ray or clinical carbon-ion beams were quantified. Hydroxyl radical (•OH), hydrogen peroxide (H2O2), and the total amount of oxidation reactions, which occurred mainly because of •OH and/or hydroperoxy radicals (HO2•), were measured by electron paramagnetic resonance-based methods. •OH generation was expected to be localized on the track/range of the carbon-ion beam/X-ray, and mM and M levels of •OH generation were observed. Total •OH generation levels were identical at the same dose irrespective of whether X-ray or carbon-ion beam irradiation was used, and were around 0.28‒0.35 μmol/l/Gy. However, sparse •OH generation levels decreased with increasing linear energy transfer, and were 0.17, 0.15, and 0.09 μmol/l/Gy for X-ray, 20 keV/μm carbon-ion beam, and >100 keV/μm carbon-ion beam sources, respectively. H2O2 generation was estimated as 0.26, 0.20, and 0.17 μmol/l/Gy, for X-ray, 20 keV/μm carbon-ion beam, and >100 keV/μm carbon-ion beam sources, respectively, whereas the ratios of H2O2 generation per oxygen consumption were 0.63, 0.51, and 3.40, respectively. The amounts of total oxidation reactions were 2.74, 1.17, and 0.66 μmol/l/Gy, respectively. The generation of reactive oxygen species was not uniform at the molecular level. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 65, 号 1, p. 1-7, 発行日 2019-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.18-34 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jcbn/advpub/0/advpub_18-34/_article | |||||
