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Risk of second cancer after ion beam radiotherapy: insights from animal carcinogenesis studies
https://repo.qst.go.jp/records/49442
https://repo.qst.go.jp/records/49442c8cc8ac9-9614-4018-b1d6-b0b85348df33
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-02 | |||||
| タイトル | ||||||
| タイトル | Risk of second cancer after ion beam radiotherapy: insights from animal carcinogenesis studies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Daino, Kazuhiro× Takabatake, Masaru× Moriyama, Hitomi× Nishimura, Yukiko× Morioka, Takamitsu× Shimada, Yoshiya× Kakinuma, Shizuko× Imaoka, Tatsuhiko× Nishimura, Mayumi× Daino, Kazuhiro× Takabatake, Masaru× Moriyama, Hitomi× Nishimura, Yukiko× Morioka, Takamitsu× Shimada, Yoshiya× Kakinuma, Shizuko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose. To review recent studies to better understand the risk of second cancer after ion beam radiotherapy and to clarify the importance of animal radiobiology therein. Results. Risk of developing second cancer after radiotherapy is a concern, particularly for survivors of childhood tumors. Ion beam radiotherapy is expected to reduce the risk of second cancer by reducing exposure of normal tissues to radiation. Large uncertainty lies, however, in the choice of relative biological effectiveness (RBE) of high linear energy transfer (LET) radiation (e.g., carbon ions and neutrons) in cancer induction, especially for children. Studies have attempted to predict the risk of second cancer after ion beam radiotherapy based on an assessment of radiation dose, the risk of low LET radiation, and assumptions about RBE. Animal experiments have yielded RBE values for selected tissues, radiation types, and age at the time of irradiation; the results indicate potentially variable RBE which depends on tissues, ages, and dose levels. Animal studies have also attempted to identify genetic alterations in tumors induced by high LET radiation. Conclusions. Estimating the RBE value for cancer induction is important for understanding the risk of second cancer after ion beam radiotherapy. More comprehensive animal radiobiology studies are needed. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 95, 号 10, p. 1431-1440, 発行日 2019-01 |
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| 出版者 | ||||||
| 出版者 | Taylor and Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553002.2018.1547848 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1547848 | |||||
