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A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas
https://repo.qst.go.jp/records/49406
https://repo.qst.go.jp/records/494066a04e7a7-65ff-48da-a1d6-4572ae197b2b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-08 | |||||
| タイトル | ||||||
| タイトル | A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hayashi, Kazuhiko
× Hayashi, Kazuhiko× Koto, Masashi× Demizu, Yusuke× Jun‐ichi, Saitoh× Suefuji, Hiroaki× Okimoto, Tomoaki× Ohno, Tatsuya× Shioyama, Yoshiyuki× Takagi, Ryo× Ikawa, Hiroaki× Nemoto, Kenji× Nakano, Takashi× Kamada, Tadashi× Hayashi, Kazuhiko× Koto, Masashi× Suefuji, Hiroaki× Okimoto, Tomoaki× Ohno, Tatsuya× Shioyama, Yoshiyuki× Takagi, Ryo× Ikawa, Hiroaki× Nemoto, Kenji× Nakano, Takashi× Kamada, Tadashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Background: We conducted a retrospective multicenter study to assess the clinical outcomes of carbon‐ion radiotherapy (CIRT) for head and neck malignancies (Japan Carbon‐Ion Radiation Oncology Study Group [J‐CROS] study: 1402 HN). We aimed to evaluate the safety and efficacy of CIRT in patients with external auditory canal (EAC) and middle ear (ME) carcinomas. Methods: Thirty‐one patients treated with CIRT at four Japanese institutions were analyzed. Fourteen patients (45.2%) had squamous cell carcinomas, 13 (41.9%) had adenoid cystic carcinomas, and four (12.9%) had other types. Nineteen (61.3%), six (19.4%), three (9.7%), and three (9.7%) patients had T4, T3, T2, and T1 disease, respectively. All patients had N0M0 status. The median radiation dose was 64 Gy (relative biological effectiveness) in 16 fractions. The median gross tumor volume was 33.3 mL. Results: The median follow‐up period was 18.4 months (range, 5.1‐85.6). The 1‐and 3‐year local control and overall survival rates were 75.0% and 55.0% and 79.3% and 58.7%, respectively. Regarding grade 3 or higher toxicities, three patients (9.7%) had grade 3 dermatitis, one (3.2%) had grade 3 mucositis, and two (6.5%) had grade 3 central nervous necrosis (ie, radiation‐induced brain necrosis). No grade 4 or worse reactions were observed. Conclusion: CIRT was effective for EAC and ME carcinomas. |
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| 書誌情報 |
Cancer Medicine 巻 8, 号 1, p. 51-57, 発行日 2019-01 |
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| 出版者 | ||||||
| 出版者 | John Wiley & Sons Ltd. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-7634 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30548207 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/cam4.1830 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/journals/1974/ | |||||
