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The Efficacy of a Custom-Made Mouthpiece With Spacer to Reduce Osteoradionecrosis in Carbon-Ion Radiation Therapy for Tongue-Base Tumor
https://repo.qst.go.jp/records/49402
https://repo.qst.go.jp/records/494021b94c978-9d86-44aa-862e-006b628d56ce
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-04 | |||||
| タイトル | ||||||
| タイトル | The Efficacy of a Custom-Made Mouthpiece With Spacer to Reduce Osteoradionecrosis in Carbon-Ion Radiation Therapy for Tongue-Base Tumor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikawa, Hiroaki
× Ikawa, Hiroaki× Koto, Masashi× K. Ebner, Daniel× Hayashi, Kazuhiko× Takagi, Ryo× Tonogi, Morio× Nomura, Takeshi× Tsuji, Hiroshi× Kamada, Tadashi× Ikawa, Hiroaki× Koto, Masashi× Hayashi, Kazuhiko× Takagi, Ryo× Tonogi, Morio× Tsuji, Hiroshi× Kamada, Tadashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction We previously demonstrated the efficacy and utility of carbon-ion radiation therapy (CIRT), finding acceptable toxicity with preserved speech and wallowing function in the setting of locally advanced tongue carcinoma. The 5-year local control rate and overall survival rate were 92.0% and 72%, respectively, among 18 patients with locally advanced adenoid cystic carcinoma of the tongue base. However, osteoradionecrosis (ORN) of the mandibular bone remains a serious adverse event for patients receiving CIRT. The incidence of grade 3 mandibular ORN was 11.1%. Further study found that the volume of maxilla receiving more than 50 Gy (relative biological effectiveness [RBE]) across 16 fractions (maxilla V50 Gy [RBE] [mL]) and the presence of teeth within the planning target volume (PTV) were significant independent risk factors for ORN. As such, reducing the volume irradiated with high dose is one key way to reduce the risk of mandibular ORN. Spacers are widely used to prevent ORN in brachytherapy for tongue ncer. However, with regard to external photon radiation therapy (RT) for tongue arcinoma,there have been no reports on the utility of spacers focused on revention of ORN, perhaps because of the dose distribution inherent to photon RT. CIRT offers improved lateral dose distribution with minimal target exit dose and thereby may benefit from the employment of a spacer-including mouthpiece. In this technical report, we introduce and evaluate the utility of a spacer-including mouthpiece with the aim of producing reduced mandible V50 for the treatment of tongue carcinoma. |
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| 書誌情報 |
Advances in Radiation Oncology 巻 4, 号 1, p. 15-19, 発行日 2019-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2452-1094 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.adro.2018.08.016 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.advancesradonc.org/article/S2452-1094(18)30148-9/fulltext | |||||
