ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

Hyperpolarized [1-(13)C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect

https://repo.qst.go.jp/records/49393
https://repo.qst.go.jp/records/49393
d200d15a-16a1-4b0c-84fa-bbee7f78ad27
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-06-04
タイトル
タイトル Hyperpolarized [1-(13)C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Scroggins, Bradley

× Scroggins, Bradley

WEKO 748152

Scroggins, Bradley

Search repository
Matsuo, Masayuki

× Matsuo, Masayuki

WEKO 748153

Matsuo, Masayuki

Search repository
O. White, Ayla

× O. White, Ayla

WEKO 748154

O. White, Ayla

Search repository
Saito, Keita

× Saito, Keita

WEKO 748155

Saito, Keita

Search repository
P. Munasinghe, Jeeva

× P. Munasinghe, Jeeva

WEKO 748156

P. Munasinghe, Jeeva

Search repository
Sourbier, Carole

× Sourbier, Carole

WEKO 748157

Sourbier, Carole

Search repository
yamamoto, Kazutoshi

× yamamoto, Kazutoshi

WEKO 748158

yamamoto, Kazutoshi

Search repository
Diaz, Vivian

× Diaz, Vivian

WEKO 748159

Diaz, Vivian

Search repository
Takakusagi, Yoichi

× Takakusagi, Yoichi

WEKO 748160

Takakusagi, Yoichi

Search repository
Ichikawa, Kazuhiro

× Ichikawa, Kazuhiro

WEKO 748161

Ichikawa, Kazuhiro

Search repository
B. Mitchell, James

× B. Mitchell, James

WEKO 748162

B. Mitchell, James

Search repository
C. Krishna, Murali

× C. Krishna, Murali

WEKO 748163

C. Krishna, Murali

Search repository
E. Citrin, Deborah

× E. Citrin, Deborah

WEKO 748164

E. Citrin, Deborah

Search repository
Takakusagi, Yoichi

× Takakusagi, Yoichi

WEKO 748165

en Takakusagi, Yoichi

Search repository
抄録
内容記述タイプ Abstract
内容記述 PURPOSE: To evaluate the potential of hyperpolarized [1-(13)C]-pyruvate magnetic resonance spectroscopic imaging (MRSI) of prostate cancer as a predictive biomarker for targeting the Warburg effect. EXPERIMENTAL DESIGN: Two human prostate cancer cell lines (DU145 and PC3) were grown as xenografts. The conversion of pyruvate to lactate in xenografts was measured with hyperpolarized [1-(13)C]-pyruvate MRSI after systemic delivery of [1-(13)C] pyruvic acid. Steady state metabolomic analysis of xenograft tumors was performed with mass spectrometry and steady state lactate concentrations were measured with proton ((1)H) MRS. Perfusion and oxygenation of xenografts was measured with electron paramagnetic resonance (EPR) imaging with OX063. Tumor growth was assessed after lactate dehydrogenase (LDH) inhibition with FX-11 (42 microg/mouse/day for 5 days x 2 weekly cycles). Lactate production, pyruvate uptake, extracellular acidification rates and oxygen consumption of the prostate cancer cell lines was analyzed in vitro. LDH activity was assessed in tumor homogenates. RESULTS: DU145 tumors demonstrated an enhanced conversion of pyruvate to lactate with hyperpolarized [1-(13)C]-pyruvate MRSI compared to PC3, and a corresponding greater sensitivity to LDH inhibition. No difference was observed between PC3 and DU145 xenografts in steady state measures of pyruvate fermentation, oxygenation, or perfusion. The two cell lines exhibited similar sensitivity to FX-11 in vitro. LDH activity correlated to FX-11 sensitivity. CONCLUSIONS: Hyperpolarized [1-(13)C]-pyruvate MRSI of prostate cancer predicts efficacy of targeting the Warburg effect.
書誌情報 Clinical Cancer Research

巻 24, 号 13, p. 3137-3148, 発行日 2018-03
出版者
出版者 AACR
ISSN
収録物識別子タイプ ISSN
収録物識別子 1078-0432
PubMed番号
識別子タイプ PMID
関連識別子 29599412
DOI
識別子タイプ DOI
関連識別子 10.1158/1078-0432.CCR-17-1957
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 18:56:46.929039
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3