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Versatile DNA folding structures organized by cationic block copolymers
https://repo.qst.go.jp/records/49386
https://repo.qst.go.jp/records/49386d7f146a1-0dac-45a8-bbdc-7d50c3fa185a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-19 | |||||
| タイトル | ||||||
| タイトル | Versatile DNA folding structures organized by cationic block copolymers | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長田, 健介
× 長田, 健介× Osada, Kensuke |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | DNA folding induced by polyion complexion with cationic polyelectrolytes (or catiomers) is attracting remarkable attention in the context of nucleosome formation during genome packaging, as well as preparation of gene vectors. The application of block catiomers, instead of homo-catiomers, is attractive as the spontaneously formed polyplex micellar structure can hamper the occurrence of secondary aggregation, allowing the folding of a single DNA molecule. Eventually, DNA is folded to form several higher-ordered structures including rod-shape, globular, and ring-shape (toroid) structures. This review aims to discuss the origin of these versatile higher-ordered structure formations by addressing the conditions and potential mechanisms underlying when and how DNA is organized into these structures upon complexation with block catiomers. |
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| 書誌情報 |
Polymer Journal 巻 51, 号 4, p. 381-387, 発行日 2019-01 |
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| 出版者 | ||||||
| 出版者 | Nature publishing group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0032-3896 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41428-018-0157-0 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41428-018-0157-0?WT.feed_name=subjects_biotechnology | |||||
