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  1. 原著論文

Updated long-term outcomes after carbon-ion radiotherapy for primary renal cell carcinoma.

https://repo.qst.go.jp/records/49372
https://repo.qst.go.jp/records/49372
2a8e5781-545e-4e2e-b620-128bc5d647c6
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-08-01
タイトル
タイトル Updated long-term outcomes after carbon-ion radiotherapy for primary renal cell carcinoma.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Kasuya, Goro

× Kasuya, Goro

WEKO 798816

Kasuya, Goro

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Tsuji, Hiroshi

× Tsuji, Hiroshi

WEKO 798817

Tsuji, Hiroshi

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Nomiya, Takuma

× Nomiya, Takuma

WEKO 798818

Nomiya, Takuma

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Makishima, Hirokazu

× Makishima, Hirokazu

WEKO 798819

Makishima, Hirokazu

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Haruyama, Yasuo

× Haruyama, Yasuo

WEKO 798820

Haruyama, Yasuo

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Kobashi, Gen

× Kobashi, Gen

WEKO 798821

Kobashi, Gen

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K Ebner, Daniel

× K Ebner, Daniel

WEKO 798822

K Ebner, Daniel

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Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 798823

Hayashi, Kazuhiko

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Omatsu, Tokuhiko

× Omatsu, Tokuhiko

WEKO 798824

Omatsu, Tokuhiko

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Kishimoto, Riwa

× Kishimoto, Riwa

WEKO 798825

Kishimoto, Riwa

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Yasuda, Shigeo

× Yasuda, Shigeo

WEKO 798826

Yasuda, Shigeo

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Igarashi, Tatsuo

× Igarashi, Tatsuo

WEKO 798827

Igarashi, Tatsuo

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Oya, Mototsugu

× Oya, Mototsugu

WEKO 798828

Oya, Mototsugu

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Akakura, Koichiro

× Akakura, Koichiro

WEKO 798829

Akakura, Koichiro

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Suzuki, Hiroyoshi

× Suzuki, Hiroyoshi

WEKO 798830

Suzuki, Hiroyoshi

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Ichikawa, Tomohiko

× Ichikawa, Tomohiko

WEKO 798831

Ichikawa, Tomohiko

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Shimazaki, Jun

× Shimazaki, Jun

WEKO 798832

Shimazaki, Jun

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Kamada, Tadashi

× Kamada, Tadashi

WEKO 798833

Kamada, Tadashi

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Working Group for Genitourinary Tumors, the

× Working Group for Genitourinary Tumors, the

WEKO 798834

Working Group for Genitourinary Tumors, the

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Kasuya, Goro

× Kasuya, Goro

WEKO 798835

en Kasuya, Goro

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Tsuji, Hiroshi

× Tsuji, Hiroshi

WEKO 798836

en Tsuji, Hiroshi

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Nomiya, Takuma

× Nomiya, Takuma

WEKO 798837

en Nomiya, Takuma

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Makishima, Hirokazu

× Makishima, Hirokazu

WEKO 798838

en Makishima, Hirokazu

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Haruyama, Yasuo

× Haruyama, Yasuo

WEKO 798839

en Haruyama, Yasuo

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Kobashi, Gen

× Kobashi, Gen

WEKO 798840

en Kobashi, Gen

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Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 798841

en Hayashi, Kazuhiko

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Omatsu, Tokuhiko

× Omatsu, Tokuhiko

WEKO 798842

en Omatsu, Tokuhiko

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Kishimoto, Riwa

× Kishimoto, Riwa

WEKO 798843

en Kishimoto, Riwa

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Yasuda, Shigeo

× Yasuda, Shigeo

WEKO 798844

en Yasuda, Shigeo

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Igarashi, Tatsuo

× Igarashi, Tatsuo

WEKO 798845

en Igarashi, Tatsuo

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Oya, Mototsugu

× Oya, Mototsugu

WEKO 798846

en Oya, Mototsugu

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Tomohiko, Ichikawa

× Tomohiko, Ichikawa

WEKO 798847

en Tomohiko, Ichikawa

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Shimazaki, Jun

× Shimazaki, Jun

WEKO 798848

en Shimazaki, Jun

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Kamada, Tadashi

× Kamada, Tadashi

WEKO 798849

en Kamada, Tadashi

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抄録
内容記述タイプ Abstract
内容記述 The long-term oncologic outcomes for primary renal cell carcinoma (RCC) treated with carbon-ion radiotherapy (CIRT) are poorly understood. Patients with primary RCC were treated with 12/16-fraction CIRT at our institution outside of clinical trials. The outcome data were pooled and retrospectively analyzed for toxicity, local control, and disease-free, cancer-specific, and overall survival. From 1997 to 2014, 19 RCC patients (11 with T1aN0M0, 4 with T1bN0M0, and 4 with inoperable advanced stage [T4N0M0, T3aN1M0, and T1aN0M1]) were treated with CIRT and followed up for a median of 6.6 (range, 0.7-16.5) years; 9 of these patients were inoperable because of comorbidities or advanced-stage disease. The diagnoses were confirmed by imaging in 11 patients and by biopsy in the remaining 8. In four of five patients with definitive renal comorbidities, including diabetic nephropathy, sclerotic kidney, or solitary kidney pre-CIRT progressed to grade 4 chronic kidney disease (CKD). In contrast, the remaining 14 patients without definitive renal comorbidities did not progress to grade 3 or higher CKD. Furthermore, although one case of grade 4 dermatitis was observed, there were no other grade 3 or higher non-renal adverse events. The local control rate, and disease-free, cancer-specific, and overall survival rates at 5- years of all 19 patients were 94.1%, 68.9%, 100%, and 89.2%, respectively. This updated retrospective analysis based on long-term follow-up data suggests that CIRT is a safe treatment for primary RCC patients without definitive renal comorbidities pre-CIRT, and yielding favorable treatment outcomes, even in inoperable cases. This article is protected by copyright. All rights reserved.
書誌情報 Cancer science

巻 109, 号 9, p. 2873-2880, 発行日 2018-09
出版者
出版者 Wiley Publishing on behalf of the Japanese Cancer Association
ISSN
収録物識別子タイプ ISSN
収録物識別子 1347-9032
PubMed番号
識別子タイプ PMID
関連識別子 29981249
DOI
識別子タイプ DOI
関連識別子 10.1111/cas.13727
関連サイト
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1111/cas.13727
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