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Updated long-term outcomes after carbon-ion radiotherapy for primary renal cell carcinoma.
https://repo.qst.go.jp/records/49372
https://repo.qst.go.jp/records/493722a8e5781-545e-4e2e-b620-128bc5d647c6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-08-01 | |||||
| タイトル | ||||||
| タイトル | Updated long-term outcomes after carbon-ion radiotherapy for primary renal cell carcinoma. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kasuya, Goro
× Kasuya, Goro× Tsuji, Hiroshi× Nomiya, Takuma× Makishima, Hirokazu× Haruyama, Yasuo× Kobashi, Gen× K Ebner, Daniel× Hayashi, Kazuhiko× Omatsu, Tokuhiko× Kishimoto, Riwa× Yasuda, Shigeo× Igarashi, Tatsuo× Oya, Mototsugu× Akakura, Koichiro× Suzuki, Hiroyoshi× Ichikawa, Tomohiko× Shimazaki, Jun× Kamada, Tadashi× Working Group for Genitourinary Tumors, the× Kasuya, Goro× Tsuji, Hiroshi× Nomiya, Takuma× Makishima, Hirokazu× Haruyama, Yasuo× Kobashi, Gen× Hayashi, Kazuhiko× Omatsu, Tokuhiko× Kishimoto, Riwa× Yasuda, Shigeo× Igarashi, Tatsuo× Oya, Mototsugu× Tomohiko, Ichikawa× Shimazaki, Jun× Kamada, Tadashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The long-term oncologic outcomes for primary renal cell carcinoma (RCC) treated with carbon-ion radiotherapy (CIRT) are poorly understood. Patients with primary RCC were treated with 12/16-fraction CIRT at our institution outside of clinical trials. The outcome data were pooled and retrospectively analyzed for toxicity, local control, and disease-free, cancer-specific, and overall survival. From 1997 to 2014, 19 RCC patients (11 with T1aN0M0, 4 with T1bN0M0, and 4 with inoperable advanced stage [T4N0M0, T3aN1M0, and T1aN0M1]) were treated with CIRT and followed up for a median of 6.6 (range, 0.7-16.5) years; 9 of these patients were inoperable because of comorbidities or advanced-stage disease. The diagnoses were confirmed by imaging in 11 patients and by biopsy in the remaining 8. In four of five patients with definitive renal comorbidities, including diabetic nephropathy, sclerotic kidney, or solitary kidney pre-CIRT progressed to grade 4 chronic kidney disease (CKD). In contrast, the remaining 14 patients without definitive renal comorbidities did not progress to grade 3 or higher CKD. Furthermore, although one case of grade 4 dermatitis was observed, there were no other grade 3 or higher non-renal adverse events. The local control rate, and disease-free, cancer-specific, and overall survival rates at 5- years of all 19 patients were 94.1%, 68.9%, 100%, and 89.2%, respectively. This updated retrospective analysis based on long-term follow-up data suggests that CIRT is a safe treatment for primary RCC patients without definitive renal comorbidities pre-CIRT, and yielding favorable treatment outcomes, even in inoperable cases. This article is protected by copyright. All rights reserved. | |||||
| 書誌情報 |
Cancer science 巻 109, 号 9, p. 2873-2880, 発行日 2018-09 |
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| 出版者 | ||||||
| 出版者 | Wiley Publishing on behalf of the Japanese Cancer Association | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-9032 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29981249 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/cas.13727 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/cas.13727 | |||||
