WEKO3
アイテム
A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity.
https://repo.qst.go.jp/records/49355
https://repo.qst.go.jp/records/4935543f34e34-a50f-4379-9eab-697b051a81b5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-25 | |||||
| タイトル | ||||||
| タイトル | A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamashita, Masahiro
× Yamashita, Masahiro× Yoshihara, Yujiro× Hashimoto, Ryuichiro× Yahata, Noriaki× Ichikawa, Naho× Sakai, Yuki× Yamada, Takashi× Matsukawa, Noriko× Okada, Go× C Tanaka, Saori× Kasai, Kiyoto× Kato, Nobumasa× Okamoto, Yasumasma× Seymour, Ben× Takahashi, Hidehiko× Kawato, Mitsuo× Imamizu, Hiroshi× Yahata, Noriaki |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions. Here, we performed predictive modeling to examine working memory ability (WMA) as a function of normative whole-brain connectivity across psychiatric diseases. We built a quantitative model for letter 3-back task performance in healthy participants, using resting state functional magnetic resonance imaging (rs-fMRI). This normative model was applied to independent participants ( = 965) including four psychiatric diagnoses. Individual's predicted WMA significantly correlated with a measured WMA in both healthy population and schizophrenia. Our predicted effect size estimates on WMA impairment were comparable to previous meta-analysis results. These results suggest a general association between brain connectivity and working memory ability applicable commonly to health and psychiatric diseases. | |||||
| 書誌情報 |
eLife 巻 7, 発行日 2018-12 |
|||||
| 出版者 | ||||||
| 出版者 | eLife Sciences Publications, Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2050-084X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30526859 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.7554/eLife.38844 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://elifesciences.org/articles/38844 | |||||
