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Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways.
https://repo.qst.go.jp/records/49290
https://repo.qst.go.jp/records/492909819fd87-f9fb-491e-9121-ca7d35a3b540
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-30 | |||||
| タイトル | ||||||
| タイトル | Genistein sensitizes glioblastoma cells to carbon ions via inhibiting DNA-PKcs phosphorylation and subsequently repressing NHEJ and delaying HR repair pathways. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Liu, Xiongxiong
× Liu, Xiongxiong× Li, Ping× Hirayama, Ryoichi× Niu, Yuzhen× Liu, Xinguo× Chen, Weiqiang× Jin, Xiaodong× Zhang, Pengcheng× Ye, Fei× Zhao, Ting× Liu, Bingtao× Li, Qiang× Xiongxiong, Liu× Li, Ping× Hirayama, Ryoichi× Jin, Xiaodong× Li, Qiang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Previously, we found genistein could sensitize cancer cells to low linear energy transfer (LET) X-rays via inhibiting DNA-PKcs activities. Especially, high-LET heavy ion produces more DNA double strand breaks (DSBs) than low-LET radiation. Thus, the study was designed to investigate the detailed molecular mechanisms of genistein on sensitizing cancer cells to heavy ions. | |||||
| 書誌情報 |
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 巻 129, 号 1, p. 84-94, 発行日 2018-10 |
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| 出版者 | ||||||
| 出版者 | Elsevier Scientific Publishers | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29685705 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radonc.2018.04.005 | |||||
