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  1. 原著論文

Direct comparison of 2‑amino[3‑11C]isobutyric acid and 2‑amino[11C]methyl‑isobutyric acid uptake in eight lung cancer xenograft models.

https://repo.qst.go.jp/records/49256
https://repo.qst.go.jp/records/49256
6a831688-28bc-47a6-9dda-27d3e2639e66
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-28
タイトル
タイトル Direct comparison of 2‑amino[3‑11C]isobutyric acid and 2‑amino[11C]methyl‑isobutyric acid uptake in eight lung cancer xenograft models.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Sudo, Hitomi

× Sudo, Hitomi

WEKO 746892

Sudo, Hitomi

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B Tsuji, Atsushi

× B Tsuji, Atsushi

WEKO 746893

B Tsuji, Atsushi

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Sugyo, Aya

× Sugyo, Aya

WEKO 746894

Sugyo, Aya

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Okada, Maki

× Okada, Maki

WEKO 746895

Okada, Maki

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Kato, Koichi

× Kato, Koichi

WEKO 746896

Kato, Koichi

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Ming-Rong, Zhang

× Ming-Rong, Zhang

WEKO 746897

Ming-Rong, Zhang

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Saga, Tsuneo

× Saga, Tsuneo

WEKO 746898

Saga, Tsuneo

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Higashi, Tatsuya

× Higashi, Tatsuya

WEKO 746899

Higashi, Tatsuya

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Sudo, Hitomi

× Sudo, Hitomi

WEKO 746900

en Sudo, Hitomi

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Tsuji, Atsushi

× Tsuji, Atsushi

WEKO 746901

en Tsuji, Atsushi

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Sugyo, Aya

× Sugyo, Aya

WEKO 746902

en Sugyo, Aya

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Okada, Maki

× Okada, Maki

WEKO 746903

en Okada, Maki

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Kato, Koichi

× Kato, Koichi

WEKO 746904

en Kato, Koichi

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Ming-Rong, Zhang

× Ming-Rong, Zhang

WEKO 746905

en Ming-Rong, Zhang

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Saga, Tsuneo

× Saga, Tsuneo

WEKO 746906

en Saga, Tsuneo

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Higashi, Tatsuya

× Higashi, Tatsuya

WEKO 746907

en Higashi, Tatsuya

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抄録
内容記述タイプ Abstract
内容記述 The non‑natural amino acid positron emission tomography tracers, 2‑amino[3‑11C]isobutyric acid ([3‑11C]AIB) and 2‑amino[11C]methyl‑isobutyric acid ([11C]MeAIB), are metabolically stable in vivo and accumulate in tumors. [3‑11C]AIB is transported into cells mainly via the amino acid transport system A and partially via systems L and ASC, whereas [11C]MeAIB is transported into cells specifically via system A. How transport via the different systems affects the tumor uptake of these tracers, however, is unclear. In the present study, the tumor uptake of the two tracers was directly compared in eight lung cancer models (A549, H82, H441, H460, H1299, H1650, PC14, and SY), and the correlation of tumor uptake with several factors (amino acid transporter expression, contribution of amino acid transport systems to AIB uptake and tumor proliferation indices) was analyzed. Biodistribution analyses revealed that the tumor uptake of [3‑11C]AIB (4.9 to 19.2% injected dose per gram [ID/g]) was higher than that of [11C]MeAIB (3.1 to 15.9% ID/g) in all eight tumors, with a statistically significant difference in three tumors (P<0.01 in H441 and H460 tumors, P<0.05 in H82 tumors). A significant correlation was observed between the tumor uptake of the two tracers (r=0.95, P<0.01). The mRNA expression levels of the amino acid transporters of system A (SLC38A1 and SLC38A2), system L (SLC7A5) and system ASC (SLC1A5) were higher in all eight tumors than in the normal lung, with widely varying expression patterns. Although the contributions of the amino acid transport systems, Ki‑67 indices and tumor doubling times greatly differed among the eight models, these factors did not correlate with the tumor uptake of either tracer. The higher tumor uptake of [3‑11C]AIB and the correlation of tumor uptake between [3‑11C]AIB and [11C]MeAIB warrant further investigation in clinical studies in order to clarify the role of [3‑11C]AIB PET in oncology imaging.
書誌情報 International journal of oncology

巻 53, 号 6, p. 2737-2744, 発行日 2018-12
出版者
出版者 D.A. Spandidos
ISSN
収録物識別子タイプ ISSN
収録物識別子 1019-6439
PubMed番号
識別子タイプ PMID
関連識別子 30334568
DOI
識別子タイプ DOI
関連識別子 10.3892/ijo.2018.4596
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