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Reduction of 223Ra retention in the large intestine during targeted alpha therapy with 223RaCl2 by oral BaSO4 administration in mice
https://repo.qst.go.jp/records/49220
https://repo.qst.go.jp/records/49220727b386d-812d-47fd-8bce-de5de83bf923
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-25 | |||||
| タイトル | ||||||
| タイトル | Reduction of 223Ra retention in the large intestine during targeted alpha therapy with 223RaCl2 by oral BaSO4 administration in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hanadate, Sayaka
× Hanadate, Sayaka× Yoshii, Yukie× Koushin, Washiyama× Yoshimoto, Mitsuyoshi× Tomoo, Yamamura× Makoto, Watanabe× Matsumoto, Hiroki× Igarashi, Mineko× Higashi, Tatsuya× Hanadate, Sayaka× Yoshii, Yukie× Koushin, Washiyama× Yoshimoto, Mitsuyoshi× Matsumoto, Hiroki× Igarashi, Mineko× Higashi, Tatsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Targeted alpha therapy with 223RaCl2 is used to treat skeletal metastases of hormone-refractory prostate cancer. The intravenous injection of 223RaCl2 causes gastrointestinal disorders such as nausea, abdominal discomfort, and diarrhea as frequent clinical adverse events caused by radiation. BaSO4 is known to display Ra2+ ion uptake in its structure and is clinically used as a contrast agent for X-ray imaging following oral administration. Here, we investigated the feasibility of a method to reduce 223Ra retention in the large intestine with BaSO4 by biodistribution studies in mice. 223RaCl2 biodistribution was examined in ddY mice after intravenous administration (10 kBq/mouse). | |||||
| 書誌情報 |
International Journal of Sciences:Basic and Applied Research 巻 42, 号 2, p. 95-105, 発行日 2018-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2307-4531 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://gssrr.org/index.php?journal=JournalOfBasicAndApplied&page=article&op=view&path%5B%5D=9429&path%5B%5D=4172 | |||||
