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Strategies to Enhance Radiosensitivity to Heavy Ion Radiation Therapy
https://repo.qst.go.jp/records/49179
https://repo.qst.go.jp/records/49179dfc92eaf-86dd-4eae-8afc-1a670eb095c6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-25 | |||||
| タイトル | ||||||
| タイトル | Strategies to Enhance Radiosensitivity to Heavy Ion Radiation Therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Lee, Younghyun
× Lee, Younghyun× Okayasu, Ryuichi× Okayasu, Ryuichi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heavy ion radiation therapy has been increasingly used due to several advantages over low linear energy transfer (LET) photon therapy, but further improvement of its therapeutic efficacy would be necessary. In this review, we summarize effective radiosensitizers for heavy ion radiation therapy and mechanisms associated with the radiosensitization. High LET heavy ions induce more complex and clustered DNA damage than low LET radiation. Inhibition of homologous recombimation repair or nonhomologous end rejoining and dysfunctional cell cycle checkpoint have been reported to sensitize cancer cells to heavy ions. Radiosenstizing agents, including DNA damage response inhibitors, Hsp90 inhibitors, histone acetylase inhibitors, and nanomaterials have been found to enhance cell killing by heavy ion irradiation through disrupted DNA damage response, cell cycle arrest, or other cellular processes. The use of these radiosensitizers could be a promising strategy to enhance the efficacy of heavy ion radiation therapy. | |||||
| 書誌情報 |
International Journal of Particle Therapy 巻 5, 号 1, p. 114-121, 発行日 2019-09 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.14338/IJPT-18-00014.1 | |||||
