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Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism
https://repo.qst.go.jp/records/49143
https://repo.qst.go.jp/records/491430bbbff9b-81e7-4f4b-bf12-c72b064ab1c3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-08-16 | |||||
| タイトル | ||||||
| タイトル | Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Somasundaram, Veena
× Somasundaram, Veena× Basudhar, Debashree× Bharadwaj, Gaurav× Hong No, Jae× A. Ridnour, Lisa× Y.S. Cheng, Robert× Fujita, Mayumi× D. Thomas, Douglas× K. Anderson, Stephen× W. McVicar, Daniel× A. Wink, David× Fujita, Mayumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Significance: Cancer is a complex disease, which not only involves the tumor but its microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific roles within tumor cells and the microenvironment and determines the rate of cancer progression, therapy efficacy, and patient prognosis. Recent Advances: Key understanding of the processes leading to dysregulated NO flux within the tumor microenvironment over the past decade has provided better understanding of the dichotomous role of NO in cancer and its importance in shaping the immune landscape. It is becoming increasingly evident that nitric oxide synthase 2 (NOS2)-mediated NO/reactive nitrogen oxide species (RNS) are heavily involved in cancer progression and metastasis in different types of tumor. More recent studies have found that NO from NOS2+ macrophages is required for cancer immunotherapy to be effective. Critical Issues: NO/RNS, unlike other molecules, are unique in their ability to target a plethora of oncogenic pathways during cancer progression. In this review, we subcategorize the different levels of NO produced by cells and shed light on the context-dependent temporal effects on cancer signaling and metabolic shift in the tumor microenvironment. Future Directions: Understanding the source of NO and its spaciotemporal profile within the tumor microenvironment could help improve efficacy of cancer immunotherapies by improving tumor infiltration of immune cells for better tumor clearance. |
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| 書誌情報 |
Antioxidants & Redox Signaling 巻 30, 号 8, 発行日 2018-05 |
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| 出版者 | ||||||
| 出版者 | Mary Ann Libert | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1523-0864 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29634348 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1089/ars.2018.7527 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1089/ars.2018.7527 | |||||
