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Neuromolecular basis of faded perception associated with unreality experience.
https://repo.qst.go.jp/records/49072
https://repo.qst.go.jp/records/490725b359a88-30fb-4bd5-b10b-37f556ec2af6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-05 | |||||
| タイトル | ||||||
| タイトル | Neuromolecular basis of faded perception associated with unreality experience. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yokokawa, Keita
× Yokokawa, Keita× Ito, Takehito× Takahata, Keisuke× Takano, Harumasa× Kimura, Yasuyuki× Ichise, Masanori× Ikoma, Yoko× Isato, Ayako× Ming-Rong, Zhang× Kawamura, Kazunori× Ito, Hiroshi× Takahashi, Hidehiko× Suhara, Tetsuya× Yamada, Makiko× Yokokawa, Keita× Ito, Takehito× Takahata, Keisuke× Takano, Harumasa× Kimura, Yasuyuki× Ichise, Masanori× Ikoma, Yoko× Isato, Ayako× Ming-Rong, Zhang× Kawamura, Kazunori× Ito, Hiroshi× Takahashi, Hidehiko× Suhara, Tetsuya× Yamada, Makiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Perceptual changes in shape, size, or color are observed in patients with derealization symptoms; however, the underlying neural and molecular mechanisms are not well understood. The current study explored the relationship between neural activity associated with altered colorfulness perception assessed by fMRI and striatal dopamine D receptor availability measured by [C]raclopride PET in healthy participants. Inside an fMRI scanner, participants performed the saturation adaptation task, where they rated how much vivid/faded visual objects looked like real/unreal ones using a visual analog scale. We found that participants experienced greater unreality when they perceived fadedness than vividness despite physically identical saturation. The combined fMRI and PET analyses revealed that the faded perception-related activities of the dorsolateral prefrontal and parietal cortex were positively correlated with striatal D receptor availability. This finding may help to understand the neuromolecular mechanisms of faded perception associated with feeling unreal in derealization symptoms. | |||||
| 書誌情報 |
Scientific Reports 巻 8, 号 1, p. 8062, 発行日 2018-05 |
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| 出版者 | ||||||
| 出版者 | Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29795167 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-018-26382-9 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-018-26382-9 | |||||
